年龄相关性黄斑变性眼底激光治疗期间血清免疫球蛋白水平的动态变化及临床意义

发布时间：2018-02-27 22:50

本文关键词： 年龄相关性黄斑变性激光光凝治疗免疫球蛋白　出处：《深圳中西医结合杂志》2016年22期 　论文类型：期刊论文

【摘要】：目的:探讨年龄相关性黄斑变性眼底激光治疗期间血清免疫球蛋白水平的动态变化及临床意义。方法:选取拟于攀枝花学院附属医院治疗的年龄相关性黄斑变性患者31例38眼。所有患者确诊后均予以激光光凝治疗,比较治疗前、治疗后4周和治疗后8周视力及血清免疫球蛋白G(Ig G)水平,并采用Pearson相关分析法分析血清Ig G水平与视力的关系。结果:患者治疗后4周,8周的视力明显高于治疗前,差异具有统计学意义(P0.05)。治疗后4周和8周的视力比较差异无统计学意义(P0.05)。患者治疗后的4周及8周的血清Ig G水平明显低于治疗前,差异具有统计学意义(P0.05),治疗后4周及8周的血清Ig G水平的差异比较差异无统计学意义(P0.05)。Pearson分析结果显示,患者的血清Ig G水平与其视力呈负相关关系(r=-0.76,P0.05)。结论:年龄相关性黄斑变性眼底激光治疗期间的视力随着时间推移逐渐上升,血清Ig G在治疗后显著下降,且在整个治疗期间逐渐下降。患者的血清Ig G水平与其视力呈负相关关系,因此,治疗前后测定年龄相关性黄斑变性患者的Ig G评估其视力并为其治疗提供指导。
[Abstract]:Objective: to investigate the dynamic changes and clinical significance of serum immunoglobulin levels during laser treatment of age-related macular degeneration. Methods: age-related macular degeneration was selected for treatment in affiliated hospitals of Panzhihua University. All patients were treated with laser photocoagulation after diagnosis. The visual acuity and serum immunoglobulin G (IGG) levels were compared before, 4 weeks and 8 weeks after treatment. Pearson correlation analysis was used to analyze the relationship between serum IgG level and visual acuity. Results: the visual acuity of patients at 4 weeks and 8 weeks after treatment was significantly higher than that before treatment. There was no significant difference in visual acuity between 4 weeks and 8 weeks after treatment. The level of serum IgG in patients at 4 and 8 weeks after treatment was significantly lower than that before treatment. The difference was statistically significant (P 0.05). There was no significant difference in serum IgG level between 4 weeks and 8 weeks after treatment. The results of Pearson analysis showed that there was no significant difference in serum IgG level between 4 weeks and 8 weeks after treatment. There was a negative correlation between serum IgG level and visual acuity. Conclusion: the visual acuity of patients with age-related macular degeneration increased gradually during laser therapy, and serum IgG decreased significantly after treatment. The serum IgG level was negatively correlated with visual acuity in patients with age-related macular degeneration before and after treatment, and provided guidance for the treatment of patients with age-related macular degeneration.
【作者单位】：攀枝花学院附属医院;
【分类号】：R779.63

【相似文献】