内皮素-1与眼科主要致盲性疾病的关系

发布时间：2018-02-27 23:41

本文关键词： 内皮素- 白内障青光眼糖尿病性视网膜病变非动脉炎性前部缺血性视神经病变　出处：《国际眼科杂志》2016年01期 　论文类型：期刊论文

【摘要】：内皮素-1(Endothelin-1,ET-1)是一种含有21个氨基酸的血管活性肽,它是目前被认为的最强的缩血管物质。它不仅具有强大的收缩血管的作用,还可以促进炎症的产生。它除了对心血管、泌尿、呼吸、消化、神经、生殖、内分泌等系统中起作用外,对眼科的备种致盲性疾病起着十分重要的作用,如内皮素-1在眼部中主要分布在脉络膜中,它对白内障的发展、青光眼眼压的升高及视神经的损害有一定联系。内皮素-1对糖尿病性视网膜病变中微血管稳态的维持及病情的诊断有一定作用;在非动脉炎性前部缺血性视神经病变中,它的浓度的高低与病变程度相吻合,对病情的判断和预后评估均有一定的临床意义。随着内皮素-1在这些疾病中的作用机制研究的不断深入,未来眼科相关疾病的预防和治疗将大有裨益。
[Abstract]:Endothelin-1 (ET-1) is a 21 amino acid vasoactive peptide, the strongest vasoconstrictor currently considered. It not only acts as a powerful vasoconstrictor, but also promotes inflammation. In addition to the functions of respiratory, digestive, nerve, reproductive, endocrine and other systems, it plays a very important role in the preparation of blinding diseases in ophthalmology, such as endothelin-1, which mainly distributes in the choroid in the eye, and plays an important role in the development of cataract. The elevation of intraocular pressure in glaucoma is associated with optic nerve damage. Endothelin-1 plays an important role in the maintenance of microvascular homeostasis and the diagnosis of diabetic retinopathy, and in non-arterial anterior ischemic optic neuropathy, endothelin-1 plays an important role in the maintenance of vascular homeostasis and the diagnosis of diabetic retinopathy. The concentration of endothelin-1 is consistent with the severity of the disease, and has certain clinical significance in judging the condition and evaluating the prognosis. As the mechanism of endothelin-1 in these diseases has been studied, the mechanism of endothelin-1 in these diseases has been further studied. The prevention and treatment of ophthalmological diseases will be of great benefit in the future.
【作者单位】：昆明医科大学;昆明医科大学第二附属医院中心实验室;昆明医科大学第二附属医院眼科;
【基金】：云南省科技计划项目(No.2013FB107)~~
【分类号】：R77

【共引文献】