扁桃体纤维母细胞性网状细胞肿瘤1例并文献复习

发布时间：2018-03-09 08:54

本文选题：扁桃体肿瘤　切入点：纤维母细胞性网状细胞肿瘤　出处：《临床与实验病理学杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的探讨纤维母细胞性网状细胞肿瘤(fibroblastic reticular cell tumor,FRCT)的临床病理学特点、诊断及鉴别诊断。方法回顾性分析1例扁桃体FRCT的临床病理学特征并复习相关文献。结果患者行右侧扁桃体肿物活检,镜下见扁桃体正常结构被破坏,肿瘤细胞增生,肿瘤细胞梭形、多边形、圆形或卵圆形,呈束状、漩涡状或席纹状排列,肿瘤细胞间可见多量散在的嗜酸性粒细胞和中性粒细胞,肿瘤细胞边界不清,细胞核呈空泡状,核膜光滑或不规则,细胞核有轻~中度异型性,可见核仁,核分裂易见(10/50 HPF)。免疫表型:肿瘤细胞Kp-1、vimentin均阳性,CK(AE1/AE3)和SMA均灶状阳性,S-100蛋白弱阳性,CD20、ALK、CD3、CD23、CD21、CD35、CD34、desmin、p63、CK5/6和CKL均阴性,EBER原位杂交检测阴性。结论 FRCT临床较少见,发生于扁桃体者更为少见,诊断主要依赖病理学及免疫表型。
[Abstract]:Objective to investigate the clinicopathological features of fibroblastic reticular cell tumors (FRCTs). Methods the clinicopathological features of a patient with tonsil FRCT were retrospectively analyzed and the relevant literatures were reviewed. Results the normal structure of tonsil was destroyed and tumor cells proliferated. Tumor cells are fusiform, polygonal, round or oval, arranged in bundles, whirlpools or sheets. A large number of scattered eosinophils and neutrophils can be seen between tumor cells. The boundaries of tumor cells are unclear, and the nuclei are vacuolated. The nuclear membrane is smooth or irregular, the nucleus has mild to moderate heterogeneity, the nucleolus can be seen. The immunophenotype: Kp-1vimentin was positive for KP-1 / AE3) and SMA was both focal positive and weakly positive for S-100 protein. CD20ALKT CD23, CD23, CD21, CD31, CD35, CD35, and CKL negative for CK5 / EB6 and CKL were negative in situ hybridization. Conclusion FRCT is rare in clinical practice, especially in tonsils, and it is more rare in tonsils, especially in tonsils, and the incidence of FRCT in tonsils is even rarer than that in tonsils, and the incidence of FRCT is more rare in tonsils than in tonsils. Diagnosis mainly depends on pathology and immunophenotype.
【作者单位】：九江学院附属医院病理科;江西省九江市第三人民医院病理科;
【分类号】：R739.64

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