Intraocular lymphoma

发布时间：2018-03-09 20:32

本文选题：intraocular　切入点：lymphoma　出处：《International Journal of Ophthalmology》2017年08期 　论文类型：期刊论文

【摘要】：Intraocular lymphoma(IOL) is a rare lymphocytic malignancy which contains two main distinct forms. Primary intraocular lymphoma(PIOL) is mainly a subtype of primary central nervous system lymphoma(PCNSL). Alternatively,IOL can originate from outside the central nervous system(CNS) by metastasizing to the eye. These tumors are known as secondary intraocular lymphoma(SIOL). The IOL can arise in the retina,uvea,vitreous,Bruch's membrane and optic nerve. There are predominantly of B-cell origin; however there are also rare T-cell variants. Diagnosis remains challenging for ophthalmologists and pathologists,due to its ability to masquerade as noninfectious or infectious uveitis,white dot syndromes,or occasionally as other metastatic cancers. Laboratory tests include flow cytometry,immunocytochemistry,interleukin detection(IL-10: IL-6,ratio 1),and polymerase chain reaction(PCR) amplification. Methotrexate-based systemic chemotherapy with external beam radiotherapy and intravitreal chemotherapy with methotrexate are useful for controlling the disease,but the prognosis remains poor. Therefore,it is important to make an early diagnose and treatment. This review is focused on the clinical manifestations,diagnosis,treatment and prognosis of the IOL.
[Abstract]:Intraocular lymphoma(IOL) is a rare lymphocytic malignancy which contains two main distinct forms. Primary intraocular lymphoma(PIOL) is mainly a subtype of primary central nervous system lymphoma(PCNSL). Alternatively,IOL can originate from outside the central nervous system(CNS) by metastasizing to the eye. These tumors are known as secondary intraocular lymphoma(SIOL). The IOL can arise in the retina,uvea,vitreous,Bruch's membrane and optic nerve. There are predominantly of B-cell origin; however there are also rare T-cell variants. Diagnosis remains challenging for ophthalmologists and pathologists,due to its ability to masquerade as noninfectious or infectious uveitis,white dot syndromes,or occasionally as other metastatic cancers. Laboratory tests include flow cytometry,immunocytochemistry,interleukin detection(IL-10: IL-6,ratio 1),and polymerase chain reaction(PCR) amplification. Methotrexate-based systemic chemotherapy with external beam radiotherapy and intravitreal chemotherapy with methotrexate are useful for controlling the disease,but the prognosis remains poor. Therefore,it is important to make an early diagnose and treatment. This review is focused on the clinical manifestations,diagnosis,treatment and prognosis of the IOL.
【作者单位】： Department
【基金】：Supported by the National Natural Science Foundation of China(No.30371515)
【分类号】：R739.7

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