保存青光眼药物对干眼症的影响

发布时间：2018-03-11 10:39

本文选题：干眼病　切入点：防腐剂　出处：《大连医科大学》2012年硕士论文　论文类型：学位论文

【摘要】：目的：本研究的主要目的是为了探讨含有防腐剂的抗青光眼药物对患者干眼的影响。方法：对100个用一种或2种抗青光眼药物治疗的青光眼患者进行干眼检测，将无任何疾病的患者陪同家属作为对照组，总共30人，不论年龄，均进行相同的干眼检测。干眼的检测主要包括泪河高度的测量和Schirmer I实验。休息10分钟后，用角膜荧光素染色测定患者泪膜破裂时间。结果：在100个患有青光眼的患者中，其中有67例患者有干眼，约占总人数的67%，33例无干眼，约占总人数的33%。其中有70%(n=14)应用阿法根（酒石酸溴莫尼定）的青光眼患者均显示阳性结果。应用派立明的青光眼患者，有87.5%(n=7)的患者能够诊断为干眼。而应用卡替洛尔的青光眼患者，干眼的患病率为69%(n=11)。应用卢美根（贝美前列腺素）的青光眼患者，有50%(n=4)患有干眼。应用曲伏前列素的患者，70%(n=7)患有干眼。应用拉坦前列素的患者，90%(n=9)有干眼的发展。在对照组，17%(n=5)的患者有干眼。一共有36个患者使用一种抗青光眼药物（阿法根或卡替洛尔），其中男性8人，女性28人。男性患者干眼的比例是50%(n=4)，而女性患者干眼的比例是75%(n=21)。有28人同时应用2种抗青光眼药物（阿法根和卡替洛尔），男性15人，女性13人，其中40%(n=6)的患者干眼实验阳性，然而女性干眼实验阳性率为69.2%9(n=9)。年龄在25-45之间的患者其干眼比例为44.4%(n=12)。年龄在46-66之间的患者其干眼发生率为72.7%(n=32)，年龄在67-87之间其干眼发生率为79.9%(n=23)。比较年龄在25-45之间的男性组与女性组患者的干眼患病率，，男性组为36.4%(n=4)，女性组为50%(n=8)。年龄在46-66之间，男性干眼患病率为58.8%(n=10)，女性为81.2%(n=22)。年龄在67-87之间的患者，男性患病率为62.5%(n=5)，女性患病率为85.7%(n=18)。结论： 1.干眼普遍存在于药物治疗的青光眼患者。 2.应用含有防腐剂的抗青光眼药物的青光眼患者其干眼检测阳性率显著增高。 3.干眼病普遍女性高于男性。 4.有效地安排干眼患者的诊断步骤。干眼检测（泪河高度，泪液分泌实验，泪膜破裂时间测定，角膜染色）相当敏感，可以用来诊断干眼病。 5.年龄同干眼病呈正相关。
[Abstract]:Objective: to investigate the effects of antiglaucoma drugs containing preservatives on dry eyes of patients. Methods: dry eye tests were performed on 100 glaucoma patients treated with one or two antiglaucoma drugs, and 30 patients, regardless of age, were included in the control group. The dry eye test mainly included the measurement of the height of the river of tears and the Schirmer I experiment. After 10 minutes of rest, the time of tear film rupture was determined by corneal fluorescein staining. Results: of the 100 patients with glaucoma, 67 had dry eyes, 33 of whom had no dry eyes. About 33% of the total. 70% of them showed positive results in glaucoma patients with arfagan (bromonidine tartrate). 87.5% of the patients were diagnosed as dry eyes, whereas those with katilol had a prevalence of 69% of dry eyes. There are 50 cases with dry eyes. 70 patients with travoprostatin have dry eyes. 90 patients with lattanprost have dry eyes. In the control group, 17 patients have dry eyes. A total of 36 patients use an anti-glaucoma drug. (Afagan or katilol, eight of whom are men, 28 women. The ratio of male patients with dry eye was 50 and that of female patients with dry eye was 75. 28 patients were treated with two kinds of anti-glaucoma drugs (Afagan and katilol, 15 males, 13 females), and 40% of them were positive for dry eye test. However, the positive rate of dry eye test in women was 69.29.The dry eye ratio of patients aged 25-45 was 44.40.The dry eye rate of patients aged 46-66 was 72.7%, and the rate of dry eye between 67-87 and 67-87 was 79.9n.Compared with men aged 25-45. The prevalence rate of dry eye in sex group and female group, The male group was 36.4% and the female group 50%. The prevalence of dry eye was 58.8% in male and 81.2% in female. The prevalence rate was 62.5% in male and 85.7% in female. Conclusion:. 1. Dry eyes are commonly found in drug-treated glaucoma patients. 2. The dry eye positive rate of glaucoma patients treated with antiseptic antiglaucoma drugs was significantly higher. 3. Dry eye disease is more common in women than in men. 4. Effective arrangement of diagnostic procedures for dry eye patients. Dry eye examination (lacrimal river height, tear secretion test, lacrimal film rupture time measurement, corneal staining) is very sensitive and can be used to diagnose dry eye disease. 5. There was a positive correlation between age and dry eye disease.
【学位授予单位】：大连医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R777.34

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