磁共振成像在中耳胆脂瘤诊断价值的Meta分析

发布时间：2018-03-15 03:32

本文选题：磁共振成像　切入点：胆脂瘤　出处：《临床耳鼻咽喉头颈外科杂志》2017年23期 　论文类型：期刊论文

【摘要】：目的:采用Meta分析综合评价磁共振成像(MR)诊断中耳胆脂瘤的价值。方法:以"cholesteatoma、MR、Magnetic Resonance"为检索词,计算机检索The Cochrane Library、PubMed等相关外文数据库,及以"胆脂瘤、磁共振成像、MR"为检索词在中国知网(CNKI)、中国生物医学文献数据库(CBM)、维普(VIP)、万方数据(Wanfang Data)中文数据库中检索MR诊断中耳胆脂瘤的相关文献,检索时间截止于2017年9月。制定严格的纳入与排除标准,由2名耳鼻咽喉头颈外科专业研究生按照上述标准,独立筛选检索相关文献并提取资料,同时采用QUADAS-2工具对纳入研究进行偏倚风险评价,最后运用Stata 12.0软件进行相关研究的Meta分析,汇总合并的敏感度、特异度等指标,绘制受试者工作特征曲线(SROC曲线)并计算曲线下面积(AUC)。结果:最终纳入21篇文献。Meta分析结果显示,MR诊断中耳胆脂瘤的Sen合并=0.88[95%CI(0.83,0.92)]、Spe合并=0.91[95%CI(0.86,0.95)]、+LR合并=10.13[95%CI(6.20,15.55)]、-LR合并=0.13[95%CI(0.09,0.19)]、DOR合并=79.23[95%CI(37.74,166.33)]、AUC=0.96[95%CI(0.93,0.97)]。亚组分析结果显示:1.5T的MR序列与3.0T的MR序列对中耳胆脂瘤诊断无明显差异。相较于回顾性研究,前瞻性研究进一步证明MR对中耳胆脂瘤有较高的诊断价值。在不同地区分析中,欧洲地区MR对中耳胆脂瘤的诊断价值更高,在这一方面的具体原因尚需进一步论证。结论:在中耳胆脂瘤的诊断方面,MR具有较高诊断价值。
[Abstract]:Objective: to evaluate the value of magnetic resonance imaging (MRM) in the diagnosis of middle ear cholesteatoma by Meta analysis. Magnetic Resonance Imaging (Mr) was used to search the relevant documents of Mr diagnosis of middle ear cholesteatoma in the Chinese database of CNKI, Chinese Biomedical Literature Database (CBMU), Vipra VIPA, Wanfang data (Wanfang data). The retrieval time was up to September 2017. Strict inclusion and exclusion criteria were established. According to the above criteria, two graduate students in head and neck surgery of otolaryngology independently screened and retrieved relevant documents and extracted data. At the same time, we use QUADAS-2 tool to evaluate the bias risk of the inclusion study, and finally use Stata 12.0 software to carry out the Meta analysis of the related research, sum up the sensitivity and specificity of the merger, etc. The area under the curve was drawn and the area under the curve was calculated. Results: the results of 21 references. Meta-analysis showed that Mr diagnosis of middle ear cholesteatoma combined with Sen was 0.88 [95CI0.830.92] SPE was combined with 0.91 [95CI0.860.95], LR combined with 10.13 (95CI6.2015.55)] -LR combined with 0.13 [95CI0.090.090.19] DOR combined with 79.23 (95CI37.4166.33)] AUC0.96 [95CI0.930.97]. The results showed that there was no significant difference in the diagnosis of middle ear cholesteatoma between Mr sequence of 1: 1.5T and Mr sequence of 3.0T. Prospective studies further demonstrated that Mr has a higher diagnostic value for middle ear cholesteatoma. In the analysis of different regions, the diagnostic value of Mr in Europe is higher than that in middle ear cholesteatoma. Conclusion: Mr imaging has high diagnostic value in the diagnosis of middle ear cholesteatoma.
【作者单位】：兰州大学第一医院耳鼻咽喉头颈外科;
【分类号】：R445.2;R764.2

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