高强度聚焦超声对离体兔眼晶状体组织形态和弹性变化的影响

发布时间：2018-03-16 18:11

本文选题：高强度聚焦超声　切入点：晶状体　出处：《激光杂志》2012年04期 　论文类型：期刊论文

【摘要】：目的:探讨不同治疗剂量高强度聚焦超声(high intensity focused ultrasound,HIFU)对兔眼晶状体组织形态和弹性变化的影响。方法:184只兔眼球随机分为空白组和HIFU组,空白组未给予HIFU辐照,HIFU组选取功率1、2W分别辐照时间3、5、8、10、15、20、25s;功率3、4、5W分别辐照时间3、58、、10、15s;辐照完后进行组织学观察以及弹性变化检测。结果:当HIFU剂量较小时,组织学观察可见晶状体辐照区形态规则,呈水滴状;当剂量增大达到一定程度时,辐照区形态不规则,可见空化效应所致大小不等的空泡。HIFU辐照晶状体后导致晶状体弹性发生变化,空白对照组、1W、3s和15s组,2W、15s组,3-5W、8s组两两比较差异无统计学意义(P0.05),余各组晶状体变化量均明显低于空白对照组,差异有统计学意义(P0.05)。结论:HIFU辐照兔眼晶状体可影响其弹性变化,在一定的能量下空化效应可恢复晶状体的弹性。
[Abstract]:Objective: to investigate the effects of high intensity focused ultrasound (HIFU) at different doses on the morphology and elasticity of lens in rabbit eyes. Methods: one hundred and eighty-four rabbits were randomly divided into blank group and HIFU group. The blank group was not given HIFU irradiation and the selected power was 1 ~ 2 W. The irradiation time was 3 ~ (5) ~ (10) ~ (10) ~ (15) ~ 20 ~ (25) s, respectively, and the irradiation time of 3 ~ 4 ~ 5 ~ 5 W was 3 ~ 5 ~ 8 ~ 10 ~ (15) s respectively. The histological observation and elastic changes were performed after irradiation. Results: when the dose of HIFU was small, Histological observation showed that the irradiated area of the lens was regular in shape, and the shape of the irradiated area was irregular when the dose increased to a certain extent. It can be seen that cavitation effect caused by different size of vacuoles. HIFU irradiation of the lens led to changes in the elasticity of the lens. There was no significant difference between the control group and the 15s group. There was no significant difference between the two groups (P 0.05), and the change of the residual lens in each group was significantly lower than that in the blank control group (P 0.05). Conclusion HIFU irradiation can affect the elastic changes of rabbit lens. The cavitation effect can restore the elasticity of the lens at a certain energy.
【作者单位】：重庆医科大学附属第二医院眼科中心;重庆明达眼科;重庆医科大学生物医学工程学院;
【基金】：重庆市卫生局重点课题(编号2010-1-25)
【分类号】：R779.6

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