MRI体积测量咽喉部血管瘤平阳霉素瘤内定量注射治疗

发布时间：2018-03-17 15:59

本文选题：咽喉部血管瘤　切入点：电子喉镜　出处：《福建医科大学》2012年硕士论文　论文类型：学位论文

【摘要】：目的：探讨在电子喉镜直视下，根据MRI扫描结果按ROI测量得到瘤体体积，“精确”定位、定量瘤内注射平阳霉素混合液治疗咽喉部血管瘤的方法及疗效，为研究和临床治疗提供参考。方法：收集2007年1月～2011年11月期间就诊福建医科大学附属第一医院耳鼻喉科门诊被诊断为咽喉部血管瘤，行MRI平扫+增强扫描诊断为海绵状血管瘤患者25例，经MRI测量瘤体体积，电子喉镜准确定位后，，利用内窥镜专用注射小针头（奥林帕斯WF-1816PN），根据瘤体体积，按比例瘤内精确定量注射平阳霉素混合液。25例患者在疗程结束后6个月，根据电子喉镜及MRI检查结果，按标准判断疗效，随访观察患者复发情况。结果：25例患者在经瘤内精确定量注射平阳霉素混合液治疗疗程结束后6个月按标准判断疗效,结果显示25例患者中20例治愈，治愈率80%；3例显效，显效率12%；有效1例，有效率4%；无效1例，无效率4%。1例（4%）患者在首次注射后1周内出现局部溃疡，三周后自行好转，1例患者（4%）出现咽部脓肿，后经收住院行“咽部脓肿切开引流术”治愈。经半年以上的随访，均未见复发。结论：根据瘤体MRI体积测量，定量控制平阳霉素瘤内介入治疗，该方法操作简单，安全可靠，治愈率高，创伤小，副作用少。
[Abstract]:Objective: to explore the method and effect of quantitative injection of pingyangmycin in the treatment of pharyngeal and laryngeal hemangioma under direct view of electronic laryngoscope and ROI measurement according to the results of MRI scan, "accurate" localization and quantitative injection of pingyangmycin in the treatment of pharynx and larynx hemangioma. To provide reference for research and clinical treatment. Methods: from January 2007 to November 2011, 25 cases of hemangioma of pharynx and larynx were diagnosed by otolaryngology, first affiliated Hospital of Fujian Medical University, and diagnosed as cavernous hemangioma by plain enhanced MRI scan. The volume of the tumor was measured by MRI. After the accurate localization of the tumor by electronic laryngoscope, the small needle was injected with the special endoscope (Orlingpas WF-1816PNN). According to the volume of the tumor, the pingyangmycin mixture was accurately and quantitatively injected into the tumor according to the volume of the tumor. 25 patients were injected with pingyangmycin mixture 6 months after the end of the course of treatment. According to the results of electronic laryngoscope and MRI, the curative effect was judged according to the standard, and the recurrence of the patients was observed. Results the curative effect of 25 cases was judged according to the standard six months after the end of the course of treatment by accurate and quantitative injection of pingyangmycin through tumor. The results showed that 20 of 25 cases were cured, the cure rate was 80% and 3 cases had remarkable effect, the effective rate was 12%, and 1 case was effective. The effective rate was 4%; the effective rate was 1 case; the ineffective rate was 4.1 cases; and the patient developed local ulcer within 1 week after the first injection, and 1 case of spontaneous improvement after 3 weeks showed a pharyngeal abscess. The patient was cured by pharyngeal abscess incision and drainage. No recurrence was found after more than half a year follow-up. Conclusion: according to MRI volume measurement, quantitative control of pingyangmycin intratumoral interventional therapy is simple, safe and reliable, high cure rate, less trauma and less side effects.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R739.6

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