变应性气道炎症动物模型研究进展

发布时间：2018-03-17 18:16

本文选题：变态反应　切入点：气道炎症　出处：《医学研究生学报》2017年09期 　论文类型：期刊论文

【摘要】：变应性气道炎症(AAI)是以气道高反应性、气道炎症反应、黏液分泌增多、气道重塑等为主要特征的病理生理过程。动物模型的构建是研究AAI相关病理生理机制的重要手段。随着生物技术的不断发展,AAI动物模型的构建发展加快。文章就AAI动物模型的动物选择、变应原选择、动物模型建立方法、动物模型评价等进行综述。
[Abstract]:Allergic airway inflammation (AAI) is characterized by airway hyperresponsiveness, airway inflammation, and increased mucus secretion. Airway remodeling is the main pathophysiological process. The construction of animal model is an important means to study the pathophysiological mechanism of AAI. With the development of biotechnology, the construction of animal model of AAI has been accelerated. Animal selection for AAI animal models, The selection of allergens, the establishment of animal models and the evaluation of animal models were reviewed.
【作者单位】：广州军区广州总医院耳鼻喉科;
【基金】：国家自然科学基金(81300817)
【分类号】：R-332;R562.25;R765.21

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