梅尼埃病患者的垂直半规管功能研究

发布时间：2018-03-25 02:33

本文选题：梅尼埃病　切入点：垂直半规管　出处：《辽宁医学院》2012年硕士论文

【摘要】：目的评估梅尼埃病（Meniere disease,MD）患者垂直半规管功能的变化并分析梅尼埃病患者垂直半规管功能与水平半规管功能的相关性。方法应用自主研发的SRM-IV全自动化良性阵发性位置性眩晕诊断治疗系统，在被检测者的垂直半规管处于垂直平面基础上，采用180°非阻尼摆动试验诱发垂直眼震，对45例正常人（对照组）及66例梅尼埃病的患者通过此方法进行垂直半规管功能检测，在诱发的同时记录下相应的眼震视频和眼震曲线，并采集垂直眼震的方向及其慢相速度（slow phase velocity，SPV）参数。计算出右前半规管与左后半规管(right anterior semicircular canal and left posterior semicircularcanal, RALP)、左前半规管与右后半规管(left anterior semicircular canal and rightposterior semicircular canal, LARP)两对垂直半规管垂直眼震平均慢相速度两侧不对称比(canal paresis,CP)。同时，对MD患者行冷热实验，筛选出水平半规管功能异常的MD患者46例，并对该46例MD患者的垂直半规管功能进行分析。结果 66例梅尼埃病患者垂直眼震引出率为96.97%（128/132），两对垂直半规管CP值范围在0.13%-89.00%，其中2例双侧MD病患者未诱发出眼震，39例至少有一对垂直半规管之CP≥20%。不论是LARP垂直平面还是RALP垂直平面，MD患者诱发出的垂直眼震平均慢相速度（ASPV）均小于正常人，t检验有统计学差异。46例水平半规管功能异常的MD患者中，，垂直半规管功能异常者有33例，除2例双侧MD患者外，其余的31例均诱发出眼震；180°非阻尼摆动试验检测出的CP之减弱方向与冷热试验之CP方向一致者为63.64%。结论梅尼埃病患者不仅有水平半规管功能异常，同时也存在垂直半规管功能的异常。运用180°非阻尼摆动试验可成功诱发垂直眼震，联合冷热试验，有助于全面了解梅尼埃病患者半规管功能。
[Abstract]:objective
Objective to evaluate the changes of vertical semicircular canal function in patients with Meniere disease (MD) and analyze the correlation between vertical semicircular canal function and horizontal semicircular canal function in patients with Meynier disease (disease).
Method
The application of independent research and development SRM-IV automation of benign paroxysmal positional vertigo diagnosis and treatment system, the vertical semicircular canal were in a vertical plane on the basis of the 180 degree non induced damping swing test vertical nystagmus, 45 cases of normal people (control group) and 66 cases of Meniere's disease patients by the method of vertical semicircular canal function detection at the same time, in the corresponding record evoked nystagmus and video nystagmus and acquisition curve, vertical nystagmus direction and slow phase velocity (slow phase, velocity, SPV). The calculated parameters of right and left anterior semicircular canal (right anterior semicircular canal and left posterior semicircularcanal, RALP), the left and right anterior posterior semicircular canal (left anterior semicircular canal and rightposterior semicircular canal, LARP) two of the vertical semicircular canal vertical nystagmus slow phase velocity average asymmetry Compared with (canal paresis, CP). At the same time, cold and hot tests for MD patients were performed. 46 cases of MD with abnormal level of semicircular canal function were screened out, and the function of vertical semicircular canal in 46 patients with MD was analyzed.
Result
66 cases of Meniere's disease patients with vertical nystagmus (128/132) extraction rate was 96.97%, two of the vertical semicircular canal CP value in the range of 0.13%-89.00%, of which 2 cases of patients with bilateral MD disease did not induce nystagmus, 39 cases at least one of the CP vertical semicircular canal is greater than or equal to 20%. whether LARP or RALP plane perpendicular to the vertical plane, the induced MD patients the average vertical nystagmus slow phase velocity (ASPV) were less than normal, t significant.46 patients with horizontal semicircular canal function abnormalities in patients with MD, the vertical semicircular canal function abnormal in 33 cases, except 2 cases of bilateral MD patients, the remaining 31 cases were induced by nystagmus; non CP direction CP weakened direction detection a damping swing test and caloric test of 180 degrees the same as 63.64%.
conclusion
Patients with Meniere's disease is not only the horizontal semicircular canal function abnormal, but also the existence of abnormal vertical semicircular canal function. By 180 degrees non damping swing test can be successfully induced by vertical nystagmus, combined with cold and hot test, is conducive to a comprehensive understanding of the canal in patients with Meniere's disease.

【学位授予单位】：辽宁医学院
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R764

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