阻塞性睡眠呼吸暂停低通气综合征患者血红蛋白、EPO及EPOR水平变化研究

发布时间：2018-04-01 01:21

本文选题：阻塞性睡眠呼吸暂停低通气综合征　切入点：血红蛋白　出处：《青海大学》2017年硕士论文

【摘要】：目的:测定并比较阻塞性呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)患者和健康对照组的红细胞计数、血红蛋白、红细胞压积、促红细胞生成素及促红细胞生成素受体水平,进一步探讨OSAHS与红细胞增生关系及发生机制。方法:收集2015年12月~2016年12月到青海大学附属医院行多导睡眠监测并确诊为OSAHS的41例汉族男性患者为病例组,平均年龄为(49.7±9.5)岁,并选取同时期到青海大学附属医院体检者32例汉族男性为对照组,平均年龄为(45.4±11.1)岁,经PSG检查后AHI5次/h,抽取清晨静脉血,测定并比较两组红细胞计数、血红蛋白、红细胞压积和睡眠监测指标,采用双抗体一步夹心法酶联免疫吸附实验法(ELISA)测定血清EPO、EPOR水平并比较。结果:1.病例组红细胞计数、血红蛋白、红细胞压积显著高于对照组[分别为5.50(5.18,5.96)vs.5.12(5.01,5.23),P=0.000;(175.5±25.0)vs.(156.9±3.8),P=0.000;50.10(47.00,54.90)vs.48.00(47.23,49.08),P=0.003],病例组和对照组EPO、EPOR无显著性差异[3.0(1.8,3.4)vs.2.6(2.0,3.9),P=0.523;6.9(5.2,8.1)vs.5.3(3.7,7.6),P=0.102],血红蛋白与氧减指数(r=0.321,P=0.041)、Sp O290%时间占总睡眠时间百分比(r=0.539,P=0.000)正相关,与最低血氧饱和度(r=-0.387,P=0.012)、平均血氧(r=-0.526,P=0.000)负相关,但与EPO、EPOR无显著线性相关。2.两组EPO与睡眠指标均无相关关系。结论:1.OSAHS患者红细胞计数、血红蛋白、红细胞压积水平明显高于健康对照组,血红蛋白与低氧密切相关,但与清晨促红细胞生成素、促红细胞生成素受体无显著线性相关。2.OSAHS患者清晨血清样本不能充分反映夜间的病理生理变化。
[Abstract]:Objective: to determine and compare the erythrocyte count, hemoglobin, hematocrit, erythropoietin and erythropoietin receptor levels in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and healthy controls.To further explore the relationship between OSAHS and erythrocyte proliferation and its mechanism.Methods: from December 2015 to December 2016, 41 male Han Chinese patients with OSAHS who were admitted to the affiliated Hospital of Qinghai University for polysomnography were collected as the case group, with an average age of 49.7 卤9.5 years.At the same time, 32 Han nationality males from the affiliated Hospital of Qinghai University were selected as the control group. The average age was 45.4 卤11.1 years old. After PSG examination, AHI5 times / h was taken out, and the red blood cell count and hemoglobin were measured and compared between the two groups.The levels of EPO-EPOR in serum were measured by double antibody one step sandwich enzyme-linked immunosorbent assay (Elisa) with hematocrit and sleep monitoring index.The result is 1: 1.There was a negative correlation with the lowest oxygen saturation (r = 0.387) and an average oxygen oxygen (n = 0. 526), but no significant linear correlation with EPOR.There was no correlation between EPO and sleep index in both groups.Conclusions 1. The erythrocyte count, hemoglobin and hematocrit in OSAHS patients were significantly higher than those in healthy controls. Hemoglobin was closely related to hypoxia, but it was associated with erythropoietin in the early morning.There was no significant linear correlation between erythropoietin receptor and erythropoietin receptor. 2. The early morning serum samples of OSAHS patients could not fully reflect the nocturnal pathophysiological changes.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R766

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