阻塞性睡眠呼吸暂停低通气综合征血栓前状态危险因素分析

发布时间：2018-04-02 04:00

本文选题：阻塞性睡眠呼吸暂停低通气综合征　切入点：血栓前状态　出处：《中国呼吸与危重监护杂志》2017年05期

【摘要】：目的分析阻塞性睡眠呼吸暂停低通气综合征(OSAHS)血栓前状态的危险因素,为OSAHS患者静脉血栓栓塞症的预防提供参考和借鉴。方法选取2014年6月至2016年7月在新疆医科大学附属第一医院经多导睡眠监测(PSG)明确诊断为OSHAS并进行了凝血、血栓与纤溶检测及炎症因子组合测定,同时排除存在其他可能影响凝血功能因素的患者共238例。其中符合血栓前状态参考标准的患者56例(即血栓前状态组),剩余182例患者凝血及血栓与纤溶检测不满足参考标准,从中随机抽取59例患者为对照组(即非血栓前状态组)。比较两组患者年龄、性别、体重指数(BMI)、睡眠呼吸暂停低通气指数(AHI)、白细胞介素-6(IL-6)、合并慢性阻塞性肺疾病(简称慢阻肺)和合并高血压的状况。结果非条件Logistic回归分析显示OSAHS血栓前状态的危险因素有年龄(OR=1.202,95%CI:1.107~1.305)、IL-6(OR=1.127,95%CI:1.014~1.252)、AHI(OR=1.151,95%CI:1.055~1.256)、合并慢阻肺(OR=4.749,95%CI:1.046~21.555)。结论年龄、AHI、IL-6、合并慢阻肺可能是OSAHS患者血栓前状态的危险因素,其中合并慢阻肺可能是最重要的危险因素。
[Abstract]:Objective to analyze the risk factors of prethrombotic state of obstructive sleep apnea hypopnea syndrome (OSAHS) and to provide reference for the prevention of venous thromboembolism in patients with OSAHS.Methods from June 2014 to July 2016, OSHAS was diagnosed by polysomnography in the first affiliated Hospital of Xinjiang Medical University, and coagulation, thrombus and fibrinolysis were detected and inflammatory factors were determined.A total of 238 patients were excluded from other possible factors affecting coagulation function.Among them, 56 patients (i.e. prethrombotic group) met the reference standard of prethrombotic state, while the remaining 182 patients did not meet the reference standard for blood coagulation and thrombus and fibrinolysis. 59 patients were randomly selected as control group (that is, non-prethrombotic state group).Age, sex, body mass index (BMI), sleep apnea hypopnea index (AHI), interleukin-6 (IL-6), chronic obstructive pulmonary disease (COPD) and hypertension were compared between the two groups.Conclusion AHI IL 6 and COPD may be the risk factors of prethrombotic status in patients with OSAHS, among which COPD may be the most important risk factor.
【作者单位】：新疆医科大学第一附属医院呼吸一科;广元市第三人民医院广元公共卫生临床医疗中心;新疆医科大学第一附属医院睡眠呼吸监测室;
【分类号】：R766

【相似文献】