频域光学相干断层扫描对糖尿病患者黄斑部视网膜厚度分区测定的研究
发布时间：2018-04-05 06:26
本文选题：频域光学相干断层扫描 切入点：糖尿病视网膜病变 出处：《眼科新进展》2012年02期
【摘要】：目的应用频域OCT分区测量正常人及各期糖尿病视网膜病变患者黄斑部视网膜厚度、黄斑部视网膜的平均厚度及黄斑部的总体积,探讨2型糖尿病患者黄斑部视网膜厚度及体积的特点以及与正常人之间的相关性。方法 2010年1月至2011年9月在我院确诊的2型糖尿病患者185例(317眼),通过常规散瞳眼底检查、眼底照相及FFA检查并依据2002年糖尿病视网膜病变国际临床分型标准将这317眼2型糖尿病患者分为3组:糖尿病正常视网膜(NDR组)患者50例(89眼)、非增生性糖尿病视网膜病变(NPDR组)患者73例(126眼)、增生性糖尿病视网膜病变(PDR组)患者62例(102眼),第4组为正常组52例(98眼)。用频域OCT对上述4组进行黄斑部的扫描,并用分析软件进行九分区的自动分析,记录各区视网膜厚度数据和黄斑区视网膜平均厚度及黄斑区总的体积。结果黄斑区以中心凹1mm为直径视网膜厚度正常组、NDR组、NPDR组、PDR组分别为(246.37±17.50)μm、(252.13±16.24)μm、(316.28±56.99)μm、(407.90±214.89)μm。4组黄斑区平均视网膜厚度分别为(285.07±10.42)μm、(289.45±11.19)μm、(332.31±39.71)μm、(390.20±64.17)μm;总体积分别为(10.22±0.39)mm3、(10.12±1.03)mm3、(11.99±3.29)mm3、(13.87±5.13)mm3。与正常组相比,NPDR、PDR组黄斑部A1-A9区视网膜厚度、黄斑部平均视网膜厚度、黄斑部总体积差异均有统计学意义(均为P0.05);NDR组与正常组相比,A1-A9区视网膜厚度、黄斑部平均视网膜厚度、黄斑部总体积差异均无统计学意义(均为P0.05);NDR、NPDR、PDR3组间以上各指标两两比较差异均有统计学意义(均为P0.05)。结论黄斑区视网膜厚度及体积与DR程度相关。频域OCT能定量定性地观察糖尿病患者黄斑区的细微变化,为糖尿病患者黄斑病变早期诊断及治疗提供可靠的检测手段。
[Abstract]:Objective to measure the macular retinal thickness, the mean macular retinal thickness and the total macular volume in normal subjects and patients with diabetic retinopathy by frequency domain OCT.To investigate the characteristics of macular retinal thickness and volume in type 2 diabetes mellitus and its correlation with normal subjects.Methods 185 patients with type 2 diabetes diagnosed in our hospital from January 2010 to September 2011 were examined by routine pupil fundus examination.Fundus photography and FFA examination were used to divide 317 eyes of type 2 diabetic patients into 3 groups according to the international clinical classification standard of diabetic retinopathy in 2002.Retinopathy NPDR group (n = 73), proliferative diabetic retinopathy group (n = 62, n = 102) and normal group (n = 52, n = 98).The macular regions of the four groups were scanned by frequency-domain OCT. The data of retinal thickness and the mean retinal thickness and the total volume of macular area were recorded by using the analysis software.缁撴灉榛勬枒鍖轰互涓績鍑，
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