鼓室内激素初始治疗突发性聋的系统评价再评价

发布时间：2018-04-08 12:39

本文选题：听觉丧失　切入点：突发性　出处：《临床耳鼻咽喉头颈外科杂志》2017年16期

【摘要】：目的:对鼓室内激素初始治疗突发性聋的Meta分析或系统评价进行再评价研究。方法:计算机检索国内外相关数据库,收集鼓室内激素初始治疗突发性聋的Meta分析或系统评价,按照纳入、排除标准筛选文献,提取出重要数据。采用AMSTAR法对其进行方法学质量评价,应用GRADE评估工具对文献的主要结局指标进行证据质量分级。结果:共纳入16个相关的系统评价或Meta分析,其中中文6篇、英文10篇,文献发表时间2009-2016年;AMSTAR评分为4~9分,14个研究为中等质量,2个研究为高质量。鼓室内激素初始治疗突发性聋的疗效不肯定。主要为两种结论:一是认为其疗效与全身激素治疗相当;二是认为鼓室内激素初始治疗突发性聋的疗效优于全身应用,部分学者推荐作为一线治疗。结论:当前鼓室内激素初始治疗突发性聋的系统评价的方法学质量水平多处于中等,结论的证据水平不高,对患者其他重要的结局指标的关注度不足。因此,更多的高质量的研究是我们的目标。
[Abstract]:Objective: to study the Meta analysis or systematic evaluation of the initial treatment of sudden deafness with intratympanic hormone.Methods: relevant databases at home and abroad were searched and Meta analysis or systematic evaluation were collected for the initial treatment of sudden deafness by hormone in tympanic chamber. The important data were extracted according to the inclusion and exclusion criteria.The AMSTAR method was used to evaluate the methodological quality and the GRADE evaluation tool was used to classify the main outcome indicators of the literature.Results: a total of 16 related systematic evaluations or Meta analyses were included, including 6 in Chinese and 10 in English. The time of publication was 4 ~ 9 in 2009-2016, 14 were of medium quality and 2 were of high quality.The effect of intracympanic hormone on sudden deafness is uncertain.There are two main conclusions: one is that the curative effect is equivalent to the whole body hormone treatment, the other is that the initial treatment of sudden deafness by hormone in tympanic chamber is better than that in the whole body, some scholars recommend it as a first line treatment.Conclusion: at present, the systematic evaluation of the initial treatment of sudden deafness by steroid in tympanic chamber is mostly of moderate quality, but the level of evidence is not high, and the attention to other important outcome indexes of patients is not enough.Therefore, more high-quality research is our goal.
【作者单位】：西南医科大学附属医院耳鼻咽喉头颈外科;西南医科大学附属医院药剂科;
【分类号】：R764.437

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