成束蛋白在喉鳞癌中的表达及其意义

发布时间：2018-04-09 05:16

本文选题：喉鳞状细胞癌　切入点：免疫组织化学　出处：《延边大学》2012年硕士论文

【摘要】：目的：探讨成束蛋白(Fascin)在喉鳞癌组织中的表达及其意义。方法：选择喉鳞癌标本41例,采用免疫组织化学二步法观察Fascin蛋白在喉鳞癌中的表达,分析Fascin表达与喉鳞癌患者的性别、年龄、民族、临床分型、临床分期、T分期、病理分化程度及淋巴结转移情况的关系。结果：41例喉鳞癌组织中,Fascin蛋白的阳性表达率为82.9%(34例),34例癌旁正常组织中Fascin蛋白阳性表达率为20.6%(7例),两者有显著性差异(P0.05)。Fascin的阳性表达,与喉鳞癌组织的临床分期、T分期及淋巴结转移情况显著相关,各组间比较均有统计学意义(P0.05)；而与患者的性别、年龄、民族、分化程度无关,各组间比较均无统计学意义(P0.05)。结论：1Fascin蛋白与喉鳞癌的侵袭、转移有关。2. Fascin蛋白的表达程度与喉鳞癌的临床分期有关。3Fascin蛋白可作为判断喉鳞癌预后的一个新指标。
[Abstract]:Objective: to investigate the expression and significance of Fascinin in laryngeal squamous cell carcinoma (LSCC).Methods: the expression of Fascin protein in laryngeal squamous cell carcinoma (LSCC) was observed by immunohistochemical two-step method in 41 cases of laryngeal squamous cell carcinoma. The expression of Fascin and sex, age, nationality, clinical type, clinical stage and T stage of laryngeal squamous cell carcinoma were analyzed.The relationship between pathological differentiation and lymph node metastasis.Results the positive expression rate of Fascin protein in 41 cases of laryngeal squamous cell carcinoma was 82.9%, and the positive rate of Fascin protein was 20.6% in 34 normal tissues of 34 cases of laryngeal squamous cell carcinoma. There was a significant difference between them.There was a significant correlation between T stage and lymph node metastasis in laryngeal squamous cell carcinoma (LSCC), but not with sex, age, nationality and differentiation.Conclusion 1 Fascin protein is related to invasion and metastasis of laryngeal squamous cell carcinoma.The expression of Fascin protein is related to the clinical stage of laryngeal squamous cell carcinoma. 3 Fascin protein can be used as a new index to judge the prognosis of laryngeal squamous cell carcinoma.
【学位授予单位】：延边大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R739.65

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