苯环喹溴铵喷鼻剂治疗感冒后急性鼻炎的临床研究

发布时间：2018-04-09 17:31

本文选题：苯环喹溴铵喷鼻剂　切入点：感冒　出处：《中国药房》2017年05期

【摘要】：目的:初步评价苯环喹溴铵喷鼻剂对感冒后急性鼻炎患者流涕症状的影响及安全性。方法:选取感冒后急性鼻炎患者238例,采用多中心、剂量平行对照、随机、双盲、安慰剂对照临床试验设计方法,将患者分为A组(24例)、B组(24例)、C组(24例)、D组(24例)、E组(23例)、F组(24例)、G组(23例)、H组(24例)、1组(24例)、J组(24例),A~C组患者分别给予苯环喹溴铵喷鼻剂22.5、45、90μg,均bid,每个鼻孔各1次;D~F组分别给予苯环喹溴铵喷鼻剂22.5、45、90μg,均tid,每个鼻孔各1次;G~I组分别给予苯环喹溴铵喷鼻剂22.5、45、90μg,均qid,每个鼻孔各1次;J组给予安慰剂。所有患者均连续治疗(4±1)d。比较10组患者流涕症状评分及流涕持续时间,并评价其安全性。结果:10组患者流涕症状评分及流涕持续时间较治疗前显著改善,差异有统计学意义(P0.05);1组患者改善情况和趋势略优于其余9组,但组间比较,差异无统计学意义(P0.05)。10组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论:苯环喹溴铵喷鼻剂90μg,qid给药治疗感冒后急性鼻炎流涕症状评分及持续时间改善趋势较为明显,安全性好。
[Abstract]:Objective: to evaluate the effect and safety of benzocycloquine bromide nasal spray on the symptoms of runny in patients with acute rhinitis after cold.Methods: 238 patients with acute rhinitis after colds were enrolled in a multicenter, dose parallel control, randomized, double-blind, placebo-controlled clinical trial.All patients were treated continuously for 4 卤1 d.The symptom score and duration of snot in 10 groups were compared and its safety was evaluated.Results the symptom score and duration of snot in the 10 groups were significantly improved as compared with those before treatment. The improvement and trend of the patients in group 1 were slightly better than those in the other 9 groups, but there was a significant difference between the two groups, but there was a significant difference between the two groups.There was no significant difference in the incidence of adverse reactions in the 10 groups. There was no significant difference in the incidence of adverse reactions (P 0.05).Conclusion: the improvement trend of symptoms and duration of acute rhinitis after colds treated with 90 渭 g of benzocycloquine bromide nasal spray is obvious and the safety is good.
【作者单位】：吴起县人民医院;第四军医大学西京医院呼吸科;四川大学华西医院呼吸科;重庆医科大学第一附属医院呼吸科;昆明医学院第一附属医院呼吸科;河北省人民医院呼吸科;天津市人民医院呼吸科;
【分类号】：R978.1

【相似文献】