青少年结膜痣12例临床病理学观察

发布时间：2018-04-10 08:59

本文选题：青少年结膜痣　切入点：结膜恶性黑色素瘤　出处：《临床与实验病理学杂志》2017年03期

【摘要】：目的探讨青少年结膜痣(juvenile conjunctival nevus,JCN)的临床病理学特征及免疫表型、诊断及鉴别诊断。方法对12例JCN进行光镜观察及免疫组化EnVision两步法染色,并复习相关文献。结果 12例患者平均年龄15.5岁,在眼球结膜、泪阜和角结膜缘可见色素性斑块。镜下均为复合痣,非黏附性痣细胞团融合性生长,且缺乏皮肤痣常见的成熟现象。痣细胞多为上皮样,大小形态较一致,整个病变中缺乏核分裂象和坏死。免疫表型:HMB-45阳性主要表达于交界区和黏膜固有层上部,Ki-67增殖指数2%~4%。结论 JCN是特殊部位发生的良性痣细胞增生性病变,需与结膜恶性黑色素瘤鉴别,临床资料、组织学改变、免疫表型及基因检测对鉴别诊断均具有重要作用。
[Abstract]:Objective to investigate the clinicopathological features, immunophenotype, diagnosis and differential diagnosis of juvenile conjunctival nevusus.Methods 12 cases of JCN were observed by light microscope and immunohistochemical EnVision two-step staining, and the related literatures were reviewed.Results the mean age of 12 patients was 15.5 years old, and pigmented plaques were seen in conjunctiva, lacrimal caruncle and Cortex conjunctiva.All of them were compound nevus under microscope. The cells of non-adherent nevus grew fused and lacked the common maturation of skin nevus.The nevus cells were mostly epithelioid, uniform in size and size, lacking mitotic and necrotic features in the whole lesion.The immunophenotype of HMB-45 was mainly expressed in the junctional area and the upper lamina propria of mucous membrane.Conclusion JCN is a benign proliferative lesion of nevus, which should be distinguished from conjunctival malignant melanoma. Clinical data, histological changes, immunophenotype and gene detection are important for differential diagnosis.
【作者单位】：湖南省吉首大学第一附属医院病理科;
【分类号】：R777.3

【相似文献】