生殖激素对正常青年人言语听性脑干反应特性的影响

发布时间：2018-04-12 22:07

本文选题：言语 + 青年人　；参考：《听力学及言语疾病杂志》2017年04期

【摘要】：目的分析正常青年人生殖激素浓度与言语诱发听性脑干反应(speech-ABR)幅值及潜伏期的相关性,探讨生殖激素对青年人言语听性脑干反应特性的影响。方法选择纯音听阈、声导抗、短声诱发听性脑干反应(click-ABR)测试均正常的青年35例为研究对象,其中女性17例(27.29±1.83岁),男性18例(28.17±2.50岁),分别行speech-ABR测试,刺激声为/da/音,采用插入式耳机,右耳给声,记录并分析各波潜伏期及波幅,同时检测血清中雌二醇、总睾酮的浓度,分析雌二醇、总睾酮的浓度与speech-ABR各波幅值及潜伏期的相关性。结果(1)女性speech-ABR各波(V、A、D、E、F、O波)潜伏期均比男性短(P0.05),V/A复合波斜度大于男性,除O波外,女青年speech-ABR其余各波幅值均显著大于男性(P0.05)。(2)女青年雌二醇水平(118.77±102.66pg/ml)显著高于男青年(52.91±14.77pg/ml)(P0.05),而总睾酮浓度(457.65±140.82pg/ml)显著低于男青年(3 677.37±1 155.80pg/ml)(P0.05)。(3)speech-ABR各波潜伏期与雌二醇浓度呈负相关(P0.05),相关系数在0.2~0.4之间,与总睾酮浓度呈正相关关系(P0.05),相关系数在0.4~0.7之间。(4)speech-ABR各波幅值随雌二醇浓度增加而增大,正向波V波与雌二醇浓度呈正相关,而负向波A、D、E、F及O波呈负相关,相关系数在0.2~0.7之间;speech-ABR各波幅值随总睾酮浓度增加而降低,起始复合波V波、A波及V/A斜率与睾酮的相关系数在0.4~0.6之间,为中度相关(P0.05);而周期性成分与睾酮浓度的相关性不强,其中D波幅值与总睾酮浓度的相关性无统计学意义(P0.05),而E波和F波的相关性也只是弱相关(P0.05);此外,结束波O波幅值与睾酮水平无关(r=0.133,P0.05)。结论生殖激素水平与speech-ABR的幅值及潜伏期存在一定相关性,可能是导致正常青年人言语诱发听性脑干反应特性性别差异的原因之一。
[Abstract]:Objective to analyze the correlation between reproductive hormone concentration and speech evoked auditory brainstem response (Speech-ABR) amplitude and latency in normal young people, and to explore the effect of reproductive hormone on the characteristics of speech auditory brainstem response in young people.Methods 35 young patients with normal auditory brainstem response (ABR), including pure tone hearing threshold, acoustic impedance and click-ABR, were selected as subjects. 17 female patients (27.29 卤1.83 years old) and 18 males (28.17 卤2.50 years old) were tested by speech-ABR.The latencies and amplitudes of each wave were recorded and analyzed by inserting earphones, and the concentrations of estradiol and total testosterone in serum were measured. The correlation between the concentrations of estradiol and total testosterone and the amplitudes and latencies of speech-ABR was analyzed.Results (1) the latency of each wave of speech-ABR in women was shorter than that in men, and the slope of V / A complex waves was higher than that of men, except O wave.There was a positive correlation with total testosterone concentration (P0.05). The correlation coefficient was between 0.4 and 0.7. The amplitudes of speech-ABR increased with the increase of estradiol concentration. The V wave was positively correlated with the concentration of estradiol, while the negative wave was negatively correlated with ADV and O waves.The correlation between D wave amplitude and total testosterone concentration was not statistically significant (P 0.05), but the correlation between E wave and F wave was only weak correlation (P 0.05), in addition, the O wave amplitude of end wave had no correlation with testosterone level.Conclusion there is a certain correlation between the reproductive hormone level and the amplitude and latency of speech-ABR, which may be one of the reasons for the sex difference of auditory brainstem response in normal young people.
【作者单位】：航天中心医院耳鼻咽喉头颈外科;首都医科大学附属北京朝阳医院耳鼻咽喉头颈外科首都医科大学耳鼻咽喉科学院耳鼻咽喉头颈科学教育部重点实验室(首都医科大学);
【基金】：首都医科大学耳鼻咽喉头颈外科教育部重点实验室开放课题基金(2012EBYH02) 北京市自然科学基金(7162066);北京市自然科学基金(7162072) 国家自然科学基金(81271090/H1304) 北京市教委科技计划重点项目(KZ201410025027)联合资助
【分类号】：R764

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