黄斑区神经节细胞复合体厚度参数在近视眼的青光眼早期诊断中应用评价

发布时间：2018-04-14 07:29

本文选题：近视眼 + 相干光断层扫描仪　；参考：《中国斜视与小儿眼科杂志》2016年04期

【摘要】：目的分析频域相干光断层扫描仪(FD-OCT)测量近视者黄斑区神经节细胞复合体(GCC)厚度参数的特点,探讨根据GCC参数对近视人群进行青光眼早期诊断时可能出现的问题。方法横断面研究。选取近视眼130眼、早期青光眼47眼、正视眼82眼,行验光、FD-OCT("GCC"模式)检查,将近视眼分为低度(L组)、中度(M组)、高度(H组)三组。分析比较近视各组与正视眼组和青光眼组的GGC平均厚度(GCC-a)及上半部(GCC-s)和下半部厚度(GCC-i)是否存在差异并评估GCC厚度参数在近视各组区分近视眼和早期青光眼的能力。结果与正视眼组比较,近视组较正视眼组薄(P0.01)。与青光眼组比较,L组和M组的GCC较青光眼组厚(P0.01)。GCC-a的丢失概率构成比在近视各组与正视组间差异均有统计学意义(x~2=91.942,P0.001)。高度近视组GCC-a的AUC仅为0.554,明显低于低度近视组(AUC=0.727)及中度近视组(AUC=0.701)。GCC-s、GCC-i在不同近视组的AUC值与GCC-a基本一致。结论近视者黄斑区GCC厚度较正视眼薄,应用FD-OCT测得的GCC厚度指标对近视者进行青光眼早期诊断时,诊断效能较差,尤其高度近视。
[Abstract]:Objective to analyze the characteristics of measuring the thickness parameters of ganglion cell complex (GCCs) in macular area of myopia by FD-OCT-FD-OCTin in frequency domain, and to explore the possible problems in the early diagnosis of myopia based on GCC parameters.Methods Cross-sectional study.130 eyes of myopia, 47 eyes of early glaucoma and 82 eyes of orthopia were examined by optometry FD-OCT ("GCC" mode).To compare the difference of GGC mean thickness (GCC-a), upper half thickness (GCC-s) and lower half thickness (GCC-I) between myopia group and orthopia group and glaucoma group, and to evaluate the ability of GCC thickness parameter to distinguish myopia from early glaucoma in myopia group.Results compared with the orthopia group, the myopia group was thinner than the orthopia group (P 0.01).Compared with glaucoma group, the loss probability ratio of GCC in L group and M group was significantly higher than that in glaucoma group (P 0.01). GCC-a was significantly different between myopia group and emmetropia group (P 0.001).The AUC of GCC-a in high myopia group was only 0.554, which was significantly lower than that in low myopia group (0.727) and moderate myopia group (AUC 0.701U. GCC-slGCC-i). The AUC values of high myopia group and moderate myopia group were basically the same as those of GCC-a group.Conclusion the thickness of GCC in macular area of myopia is thinner than that in normal eyes. The early diagnosis of glaucoma in myopic patients with GCC thickness measured by FD-OCT has poor diagnostic efficacy, especially in high myopia.
【作者单位】：北京大学第一医院视觉损伤与修复教育部重点实验室;北京大学第一医院医学统计室;
【分类号】：R775.1;R778.11

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