成人共同性外斜视脑功能连接网络的静息状态功能磁共振成像研究

发布时间：2018-04-18 05:16

本文选题：斜视 + 神经影像　；参考：《南昌大学》2017年硕士论文

【摘要】：目的:应用3.0T功能性磁共振成像(functional magnetic resonance imaging,fMRI,)探究成人共同性外斜视(comitant exotropia strabismus,CES)患者静息态大脑功能网络活动的变化,并运用基于体素的度中心度((Voxel-wise degree centrality,DC)方法分析探讨大脑活动变化。方法:对CES组30例(17男13女)和与其年龄、性别及教育程度相匹配的健康对照组(HCs)(17男13女)分别进行fMRI扫描。运用DC方法来评估自发的大脑活动功能网络变化。运用受试者工作特征曲线(ROC曲线)来分析CESs患者与HCs的DC信号值的区别,从而探讨共同性外斜视患者大脑网络活动的变化。结果:相比于健康对照组,CES患者DC值降低区域包括右小脑后叶,右额下回,右侧额中回和右顶上小叶/初级躯体感觉皮质(S1);DC值增加区域为右颞上回,双侧前扣带回和左顶下小叶。结论:成人外斜视患者伴随着多处大脑功能网络异常,这些异常揭示了共同性外斜视可能是一种涉及中枢神经系统异常的疾病。
[Abstract]:Aim: to investigate the changes of resting brain functional network activity in adult comitant exotropia strabismus (CESs) patients with concomitant exotropia by using 3.0T functional magnetic resonance imaging.Voxel-wise degree centrality DCA (Voxel-wise degree centrality) method based on voxel was used to analyze the changes of brain function network in adult patients with concomitant exotropia.Methods: fMRI scans were performed in 30 CES patients (17 males and 13 females) and 17 healthy controls matched with their age, sex and educational level.DC method was used to evaluate the changes of spontaneous brain function network.The difference of DC signal between CESs patients and HCs patients was analyzed by using the operating characteristic curve (ROC curve), and the changes of brain network activity in concomitant exotropia patients were discussed.Results: compared with the healthy control group, the decreased DC value in CES patients included right posterior cerebellar lobe, right inferior frontal gyrus, right middle frontal gyrus and right superior parietal lobe / primary somatosensory cortex.Bilateral anterior cingulate gyrus and left inferior parietal lobules.Conclusion: adult exotropia patients are accompanied by multiple brain functional network abnormalities which suggest that concomitant exotropia may be a disease involving central nervous system abnormalities.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R445.2;R777.41

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