E-钙黏蛋白异常表达与鼻咽癌临床病理关系的Meta分析

发布时间：2018-04-22 10:35

本文选题：E-钙黏蛋白 + 异常表达　；参考：《癌变·畸变·突变》2016年02期

【摘要】：目的:探讨E-钙黏蛋白(E-cadherin)在鼻咽癌组织中的异常表达与临床病理的关系,为临床提供参考。方法:计算机检索Cochrane Library、Pubmed、EMbase数据库以及中国生物医学文献数据库、中国学术期刊全文数据库中有关E-cadherin与鼻咽癌研究的文献,采用STATA 11.0软件包进行分析。异常表达、分化程度、T分期、淋巴结转移状况及临床分期采用优势比(OR)及95%可信区间(CI)作为效应量进行分析。结果:入选16篇文献共包括1 040例鼻咽癌患者,结果显示E-cadherin在鼻咽癌组织中的异常表达较正常对照组明显增加(OR=0.096,95%CI:0.036~0.252,P=0.000);E-cadherin异常表达与分化程度、淋巴结转移及临床分期明显相关(OR=0.232,95%CI:0.061~0.884,P=0.032;OR=0.324,95%CI:0.198~0.531,P=0.000;OR=0.441,95%CI:0.232~0.835,P=0.012)。E-cadherin异常表达者肿瘤分化程度低,更易出现淋巴结转移,肿瘤分期偏晚。结论:E-cadherin在鼻咽癌组织中存在异常表达。E-cadherin可以作为鼻咽癌患者分化程度、淋巴结转移及临床分期的判断指标,值得进一步深入研究。
[Abstract]:Objective: to investigate the relationship between the abnormal expression of E-cadherin and clinicopathology in nasopharyngeal carcinoma (NPC). Methods: the Cochrane Library Pubmedus Embase database, the Chinese biomedical literature database, and the literatures on E-cadherin and nasopharyngeal carcinoma in the full text database of Chinese academic journals were searched and analyzed by STATA 11.0 software package. Abnormal expression, differentiation and T stage, lymph node metastasis and clinical staging were analyzed by odds ratio (ORR) and 95% CI (confidence interval). Results: a total of 1 040 NPC patients were included in 16 articles. The results showed that the abnormal expression of E-cadherin in nasopharyngeal carcinoma tissues was significantly higher than that in the normal control group. The abnormal expression and differentiation of E-cadherin in NPC tissues were significantly increased. Lymph node metastasis and clinical stage were significantly correlated with lymph node metastasis and clinical stage in patients with abnormal expression of 0.232C95 CI0.061C 0.884C / P 0.032 / 0.3241CIO: 0.198 0.531P0.000 / 0.44195 / 0.232CIO: 0.8232P0.01212.E-cadherin was more likely to present lymph node metastasis, and tumor stage was later than that of the control group (P = 0.232P 0.012.E-cadherin = 0.232P 0.012.E-cadherin = 0.232P 0.012.E-cadherin) was more likely to appear lymph node metastasis, and tumor stage was late. Conclusion the abnormal expression of .E-cadherin in nasopharyngeal carcinoma can be used as a diagnostic index for differentiation, lymph node metastasis and clinical stage of NPC patients, which is worthy of further study.
【作者单位】：河北医科大学第四医院放疗科;河北医科大学第四医院超声科;保定市第七医院肿瘤科;河北医科大学第四医院耳鼻咽喉-头颈外科;
【基金】：河北省医学科学研究重点课题计划资助项目(ZL20140174)
【分类号】：R739.63

【相似文献】