高压氧联合鼓室灌注激素治疗突发性耳聋的疗效及对血液流变学的影响

发布时间：2018-04-22 11:06

本文选题：突发性耳聋 + 高压氧　；参考：《中国老年学杂志》2016年19期

【摘要】：目的探讨高压氧联合鼓室灌注激素治疗突发性耳聋的疗效及对血液流变学的影响。方法突发性耳聋患者150例,按随机数字表法分为激素组、高压氧组和联合组各50例。所有患者均常规给予扩血管、营养神经及活血化瘀等药物治疗,在此治疗基础上,高压氧组采用高压氧治疗,激素组患者经鼓室灌注甲泼尼龙琥珀酸钠40 mg,联合组患者采用高压氧及鼓室灌注甲泼尼龙琥珀酸钠40 mg联合治疗。比较三组患者的听阈水平、疗效、血流变的改变情况及不良反应发生情况。结果三组患者听阈提高水平及治疗有效率比较差异显著(P0.05),依次为联合组激素组高压氧组。三组患者治疗前的血液流变学指标无差异(P0.05),经治疗三组患者的血流变指标较治疗前均明显改善,且联合组各项指标的改善情况均优于激素组和高压氧组(P0.05),激素组与高压氧组比较无差异(P0.05)。三组不良反应发生率比较无差异(P0.05)。结论高压氧和鼓室灌注激素联合治疗能明显改善突发性耳聋患者的血流变指标,恢复患者听力,可在临床借鉴使用。
[Abstract]:Objective to investigate the effect of hyperbaric oxygen combined with tympanic perfusion hormone on sudden deafness and its effect on hemorheology. Methods 150 patients with sudden deafness were randomly divided into hormone group, hyperbaric oxygen group and combined group. All the patients were treated with vasodilator, nutritional nerve, blood circulation and blood stasis. On the basis of this treatment, the hyperbaric oxygen group was treated with hyperbaric oxygen. The patients in the hormone group were treated with 40 mg methylprednisolone sodium succinate through the tympanic chamber, and the patients in the combined group were treated with hyperbaric oxygen and 40 mg sodium methylprednisolone succinate in the tympanic chamber. The hearing threshold level, curative effect, hemorrheological changes and adverse reactions were compared among the three groups. Results there were significant differences in the level of hearing threshold and the effective rate of treatment among the three groups (P 0.05), followed by hyperbaric oxygen group in the combined group. There was no difference in hemorheological indexes between the three groups before treatment. The hemorheological indexes of the three groups were significantly improved compared with those before treatment. The improvement of each index in the combined group was better than that in the hormone group and the hyperbaric oxygen group (P 0.05), but there was no difference between the hormone group and the hyperbaric oxygen group (P 0.05). There was no difference in the incidence of adverse reactions among the three groups (P 0.05). Conclusion the combination of hyperbaric oxygen and tympanic perfusion hormone can significantly improve the hemorheological index of sudden deafness patients and recover the hearing of the patients, which can be used for reference in clinical practice.
【作者单位】：河北省人民医院耳鼻喉科;
【分类号】：R764.437

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