原发性闭角型青光眼患者丘脑—皮层通路的静息态fMRI功能连接

发布时间：2018-04-26 23:38

本文选题：青光眼 + 闭角　；参考：《中国医学影像技术》2017年02期

【摘要】：目的利用静息态fMRI技术,探讨原发性闭角型青光眼(PACG)患者丘脑—皮层通路功能连接的变化。方法25例PACG患者(PACG组)和22名性别与年龄匹配的健康志愿者(对照组)均接受静息态fMRI。将双侧丘脑的各7个亚区作为ROI,分别为初级运动、感觉、枕叶、前额叶、前运动、后顶叶及颞叶丘脑ROI,与全脑皮层体素作静息态fMRI功能连接分析,并进行组间两独立样本t检验。结果与对照组比较,PACG组丘脑与视觉传导通路(顶叶/楔前叶、额叶/额下回)及非视觉传导通路(中央旁小叶、中央后回、边缘叶/海马旁回)功能连接减低,丘脑与视觉传导通路(枕叶、顶叶/顶下小叶、颞叶/颞下回)以及非视觉传导通路(小脑前叶/山顶)功能连接增加。结论 PACG患者存在包括丘脑视觉传导通路及非视觉传导通路的连接异常,提示丘脑在PACG患者神经学发病机制中起着重要作用。
[Abstract]:Objective to investigate the changes of functional junction of thalamus-cortical pathway in patients with primary angle-closure glaucoma by resting fMRI technique. Methods Twenty-five patients with PACG and 22 age-matched healthy volunteers (control group) received rest fMRI. Seven subregions of bilateral thalamus were used as ROI, which were primary motor, sensory, occipital, prefrontal, premotor, posterior parietal and temporal thalamus, respectively. Two independent samples were tested by t-test. Results compared with the control group, the functional connections between thalamus and visual conduction pathway (parietal / precuneal lobe, frontal lobe / inferior frontal gyrus) and non-visual conduction pathway (paracentral lobules, posterior central gyrus, marginal lobe / perihippocampal gyrus) were decreased in PACG group. The functional connections between thalamus and visual conduction pathway (occipital lobe, parietal / subparietal lobe, temporal lobe / infratemporal gyrus) and non-visual conduction pathway (anterior cerebellar lobe / peak) were increased. Conclusion there are abnormal connections between the visual conduction pathway and the non-visual conduction pathway in the patients with PACG, suggesting that the thalamus plays an important role in the neuropathogenesis of PACG patients.
【作者单位】：南昌大学第一附属医院影像科;
【基金】：国家自然科学基金(81360219)
【分类号】：R775.2

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