胚胎干细胞向体表外胚层及角膜上皮细胞分化过程中信号通路的调节

发布时间：2018-04-27 00:03

本文选题：胚胎干细胞 + 外胚层　；参考：《中国药理学与毒理学杂志》2017年02期

【摘要】：干细胞泛指体外具有自我更新和多向或定向分化潜能的细胞,胚胎干细胞则可被诱导分化形成内胚层、中胚层及外胚层来源的200余种不同细胞。角膜上皮细胞来源于胚胎发育时期的表皮外胚层。临床上严重、广泛的眼表损伤,需要具有增殖能力的角膜上皮细胞修复损伤。利用体内外研究体系模拟体内胚胎发育及组织环境,阐明具有生物活性的角膜上皮细胞的发育过程,为再生医学提供依据,是近年来研究的热点之一。本文介绍了Notch、Wnt、骨形态发生蛋白及成纤维生长因子等调控表皮外胚层发育及与角膜上皮细胞分化相关的信号通路,以既往实验研究为基础,就各信号通路调控的机制及主要调控因子进行综述。
[Abstract]:Stem cells generally refer to the cells with the potential of self-renewal and multi-directional or directional differentiation in vitro, while embryonic stem cells can be induced to differentiate into more than 200 different types of cells from the endoderm, mesoderm and ectoderm. Corneal epithelial cells are derived from the epidermal ectoderm during embryonic development. Severe and extensive ocular surface injury is needed for corneal epithelial cells with proliferative ability. It is one of the hot research topics in recent years to simulate the embryonic development and tissue environment in vivo and in vitro and to elucidate the development process of corneal epithelial cells with biological activity and provide the basis for regenerative medicine. In this paper, Notchus Wnt, bone morphogenetic protein (BMP) and fibroblast growth factor (FGF) are introduced to regulate epidermal ectodermal development and signal pathways related to corneal epithelial cell differentiation. The mechanism and main regulatory factors of signal pathway regulation were reviewed.
【作者单位】：解放军总医院眼科;吉林大学第一医院眼科中心;
【基金】：国家973重点基础研究发展计划(2013CB967001) 国家自然科学基金(31271059);国家自然科学基金(81670830)~~
【分类号】：R772.2

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