肿瘤坏死因子α、白细胞介素6、C反应蛋白与阻塞性睡眠呼吸暂停低通气综合征相关肺动脉高压的相关性研究

发布时间：2018-04-27 10:56

  本文选题：阻塞性睡眠呼吸暂停低通气综合征 + 肺动脉高压　； 参考：《中国呼吸与危重监护杂志》2016年03期

【摘要】：目的探讨血清肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、C反应蛋白(CRP)与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)相关肺动脉高压(PH)的关系。方法收集宁夏医科大学总医院2013年9月至2014年10月OSAHS患者38例及OSAHS相关PH患者32例,健康对照组35例。采用多导睡眠监测仪诊断OSAHS,超声心动图测量肺动脉收缩压(PASP),以PASP≥40 mm Hg为PH标准,酶联免疫吸附法检测血清TNF-α、IL-6、CRP及内皮素1(ET-1)水平。结果三组人群血清TNF-α、IL-6、CRP、ET-1水平差异有统计学意义(F=55.34、25.05、23.85、34.06,P0.05),两两比较发现OSAHS组各因子水平高于健康对照组(P0.05),OSAHS相关PH组各因子水平高于健康对照组及OSAHS组(P0.05);PASP与四项炎性因子均呈正相关关系(r=0.755、0.762、0.747、0.759,均P0.01)。结论血清TNF-α、IL-6、CRP水平与OSAHS相关PH有相关性,提示这类炎性因子参与了OSAHS相关PH的形成。
[Abstract]:Objective to investigate the relationship between serum tumor necrosis factor- 伪 (TNF- 伪), interleukin-6 (IL-6) -C-reactive protein (CRP) and pulmonary hypertension associated with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods from September 2013 to October 2014, 38 patients with OSAHS, 32 patients with OSAHS associated PH and 35 healthy controls were collected from the General Hospital of Ningxia Medical University. OSAHS was diagnosed by polysomnography, pulmonary arterial systolic blood pressure (PASP) was measured by echocardiography, serum TNF- 伪 IL-6 CRP and endothelin 1 (ET-1) were measured by enzyme-linked immunosorbent assay (Elisa) with PASP 鈮，

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