84例唇腭裂患者听觉失匹配负波的研究

发布时间：2018-05-06 15:56

本文选题：腭裂 + 唇裂　；参考：《中华耳科学杂志》2017年01期

【摘要】：目的对纯音测听(pure tone audiometry,PTA)、听性脑干反应(auditory brain stem response,ABR)正常的唇腭裂患者行听觉失匹配负波(auditory mismatch negativity,AMMN)检查,并与健康正常人对照,判断唇腭裂患者听觉皮层的功能状态,为探讨其言语功能障碍机制提供理论依据。方法唇裂伴有腭裂(Cleft Lip and Palate,CLP)39例,单纯唇裂(Cleft Lip,CL)28例,单纯腭裂(Cleft Palate,CP)17例,健康志愿者(正常组)39例(纯音测听、听性脑干反应均正常)分别行AMMN检查,比较各组间潜伏期及波幅的差异。结果 CP组AMMN潜伏期较正常组、CL组显著延长(P0.05),CP组潜伏期较CLP组无明显差异(P0.05);CLP组潜伏期较CL组、正常组显著延长(P0.05);CL组潜伏期与正常组无明显差异(P0.05)。各组间AMMN的波幅无明显差异(P0.05)。结论 CP及CLP患者听觉皮层的功能可能存在异常,可能为导致其言语功能障碍的一个原因,但仍然需要结合其言语识别能力、言语功能评定、磁共振(magnetic resonance,MR)、功能性磁共振(functional magnetic resonance imaging,fMRI)加以进一步研究。
[Abstract]:Objective to evaluate the functional status of auditory cortex in patients with normal auditory brainstem response (ABR), pure tone audiometry and auditory brainstem response (ABR). Methods the patients with cleft lip and palate were examined by auditory mismatch negative mismatch (AMMNs), and compared with those of healthy controls, and to determine the functional status of auditory cortex in patients with cleft lip and palate, and to determine the function of auditory cortex in patients with cleft lip and palate, and to evaluate the function of auditory cortex in patients with cleft lip and palate. To provide a theoretical basis for exploring the mechanism of speech dysfunction. Methods AMMN examination was performed in 39 patients with cleft Lip and palatography, 28 patients with cleft and 17 patients with cleft palatal cleft palsy. 39 normal subjects (pure tone audiometry and normal auditory brainstem response) were examined by AMMN. The latency and amplitude of each group were compared. Results the latent period of AMMN in CP group was significantly longer than that in control group. There was no significant difference in latency of CP group compared with that of CLP group, but there was no significant difference between normal group and normal group. There was no significant difference in the amplitude of AMMN among groups (P 0.05). Conclusion the abnormal function of auditory cortex may be one of the causes of speech dysfunction in CP and CLP patients, but it is still necessary to evaluate the speech function in combination with their speech recognition ability. Magnetic resonance and functional magnetic resonance imaging of MRI were further studied.
【作者单位】：安徽医科大学解放军306临床学院耳鼻咽喉头颈外科;解放军第306医院耳鼻咽喉科头颈外科;北京大学口腔医学院唇腭裂治疗中心;
【分类号】：R764;R782.2

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