嗜酸粒细胞分类伴息肉型慢性鼻-鼻窦炎的临界值观察

发布时间：2018-05-11 15:28

本文选题：嗜酸粒细胞 + 鼻窦炎　；参考：《安徽医科大学学报》2017年08期

【摘要】：目的探索以组织嗜酸粒细胞(Eos)浸润程度来分类伴鼻息肉型慢性鼻-鼻窦炎(CRSw NP)可能存在的临界值。方法收集140例CRSw NP患者术前临床资料,术中收集鼻息肉组织评估组织Eos,术后3个月和6个月时随访。结果将组织Eos以≤50个Eos/高倍镜视野(HPF)为临界点分组时,术前视觉模拟、鼻窦CT、鼻内镜评分,术后3个月及6个月鼻内镜评分差异有统计学意义(P0.05);变应原皮肤试验阳性组与阴性组的组织Eos间差异无统计学意义;组织Eos与外周血Eos百分比及绝对值在置信度为0.01时呈显著相关性(ρ=0.459、0.473,P0.01)。结论对区分嗜酸粒细胞型鼻窦炎与非嗜酸粒细胞型鼻窦炎最有意义的临界点可能在50个Eos/HPF附近(取息肉组织,随机HPF);变应性因素可能对CRSw NP患者鼻息肉组织的Eos增多无影响或影响不大;外周血Eos可能能够成为代表组织Eos高低的一项指标。
[Abstract]:Objective to explore the possible critical value of tissue eosinophil (Eos) infiltration to classify chronic rhinosinusitis (CRSw NP) with nasal polyps. Methods 140 patients with CRSw NP were collected before operation, and the nasal polyp tissue was collected to evaluate the tissue Eos, 3 months and 6 months after operation. The result was to organize Eos with less than 50 Eos/ high magnification lenses. When the visual field (HPF) was divided into critical points, preoperative visual simulation, sinus CT, nasal endoscopy score, 3 months and 6 months after the operation were statistically significant (P0.05), and there was no statistical difference between the positive group and the negative group Eos; the percentage and absolute value of Eos in the tissue Eos and the peripheral blood were 0.01 when the confidence was 0.01. Significant correlation (rho =0.459,0.473, P0.01). Conclusion the most significant critical point for differentiating eosinophil type sinusitis and non eosinophilic sinusitis may be near 50 Eos/HPF (polyp tissue, random HPF); allergic factors may not affect or have little influence on Eos increase in nasal polyps of CRSw NP patients; peripheral blood Eos may be not affected. It can be an indicator of the level of the organization's Eos.

【作者单位】：安徽医科大学附属省立医院耳鼻咽喉头颈外科;
【基金】：安徽省国际科技合作计划项目(编号:11030603026)
【分类号】：R765.9

【相似文献】