鼻腔和鼻窦鳞状细胞癌细胞中PRL-3及VEGF表达的临床意义

发布时间：2018-05-11 20:54

本文选题：鳞状细胞癌 + 促肝细胞再生磷酸酶-　；参考：《临床耳鼻咽喉头颈外科杂志》2016年13期

【摘要】：目的:探讨促肝细胞再生磷酸酶-3(PRL-3)和血管内皮生长因子(VEGF)在鼻腔、鼻窦鳞状细胞癌(SNSCC)中表达的临床意义。方法:采用免疫组织化学及RT-PCR方法检测62例SNSCC组织(SNSCC组)、30例鼻息肉组织(NP组)以及25例正常鼻腔黏膜(NM组)中PRL-3和VEGF的表达情况。结果:1SNSCC组中PRL-3和VEGF的表达明显高于NP组及NM组,差异有统计学意义(P0.05);2SNSCC组中PRL-3和VEGF的表达情况在不同性别、年龄患者中无明显差别(P0.05),而随着TNM分期的增高、分化程度的降低及伴淋巴结转移,PRL-3和VEGF的表达明显增高(P0.05);3在SNSCC组中PRL-3以及VEGF的表达呈正相关(r=0.468,P0.05)。结论:PRL-3及VEGF在SNSCC的增殖与分化调控中可能起到了重要作用,PRL-3和VEGF的高表达可反映SNSCC细胞的增殖活性,二者可能在肿瘤的侵袭转移过程中起到了协同促进作用。
[Abstract]:Objective: to investigate the clinical significance of hepatocyte regeneration promoting phosphatase-3 (PRL-3) and vascular endothelial growth factor (VEGF) expression in nasal cavity and sinusoidal squamous cell carcinoma (SNSCC). Methods: immunohistochemical and RT-PCR methods were used to detect the expression of PRL-3 and VEGF in 62 cases of SNSCC and 30 cases of nasal polyps (NP group) and 25 cases of normal nasal mucosa (NM group). Results the expression of PRL-3 and VEGF in SNSCC group was significantly higher than that in NP group and NM group. There was a significant difference in the expression of PRL-3 and VEGF between the two groups. There was no significant difference in the expression of PRL-3 and VEGF in different sex and age group, but with the increase of TNM stage. The degree of differentiation and the expression of PRL-3 and VEGF in patients with lymph node metastasis were significantly increased in SNSCC group. The expression of PRL-3 and VEGF was positively correlated with the expression of PRL-3 and VEGF in SNSCC group. Conclusion the high expression of PRL-3 and VEGF may play an important role in the regulation of proliferation and differentiation of SNSCC. The high expression of PRL-3 and VEGF may reflect the proliferative activity of SNSCC cells, and they may play a synergistic role in the process of tumor invasion and metastasis.
【作者单位】：承德医学院附属医院耳鼻咽喉科;承德医学院附属医院体检科;
【基金】：承德市科学技术研究与发展计划项目(No:201601A047)
【分类号】：R739.62

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