慢性鼻—鼻窦炎及变应性鼻炎鼻粘膜上皮细胞屏障功能的破坏及紧密连接蛋白表达的变化

发布时间：2018-05-13 02:10

本文选题：慢性鼻-鼻窦炎(Chronic + rhinosinusitis)　；参考：《南昌大学》2017年硕士论文

【摘要】：鼻炎(Rhinitis)被认为是鼻腔黏膜的炎症性疾病,高达40%的人群患有鼻炎。在所有引起鼻腔黏膜炎症性疾病当中,变应性鼻炎(allergic rhinitis,AR)是最常见的一种,占1/6比重。AR的一系列临床症状严重影响人们的日常生活,降低睡眠质量和工作效率。目前AR被认为是呼吸道系统疾病的表现,且AR患者常伴发哮喘。过敏性哮喘患者的气道上皮呈现不同程度的损伤,包括连接蛋白表达的减少,对损伤的敏感性增加,及组织重塑。慢性鼻-鼻窦炎(Chronic rhinosinusitis,CRS)是一种鼻腔鼻窦黏膜炎症性疾病,临床发病率高,影响15%的人群,且炎症影响患者生活质量和工作效率。其发病机制尚不明确。目前,多项研究证明慢性炎症性疾病,例如哮喘、皮肤病、Crohn病等,与黏膜上皮细胞紧密连接蛋白表达的改变、上皮屏障功能破坏相关。目前一些研究认为,慢性鼻-鼻窦炎患者鼻黏膜亦涉及上皮细胞屏障功能的破坏及紧密连接相关蛋白表达的改变。本文旨在对慢性鼻-鼻窦炎及变应性鼻炎鼻腔黏膜上皮细胞屏障功能的破坏及紧密连接蛋白表达变化的研究进展进行综述,试图从鼻黏膜上皮屏障功能层面进一步研究慢性鼻-鼻窦炎及变应性鼻炎的发病机制。
[Abstract]:Rhinitis is considered to be an inflammatory disease of nasal mucosa, with up to 40% of the population suffering from rhinitis. Among all the inflammatory diseases causing nasal mucosa, allergic rhinitis ARs is the most common one. A series of clinical symptoms, which account for 1 / 6 proportion, seriously affect people's daily life, reduce sleep quality and work efficiency. At present, AR is considered to be a manifestation of respiratory system diseases, and AR patients often develop asthma. Airway epithelium in patients with allergic asthma showed varying degrees of injury, including reduced expression of connexin, increased sensitivity to injury, and tissue remodeling. Chronic rhinosinusitis (CRS) is a kind of inflammatory disease of nasal cavity and sinusitis mucosa, which has a high clinical incidence and affects 15% of the population, and inflammation affects the quality of life and work efficiency of the patients. Its pathogenesis is not clear. At present, several studies have shown that chronic inflammatory diseases, such as asthma, skin disease and Crohn's disease, are related to the changes of tight junction protein expression in mucosal epithelial cells and the destruction of epithelial barrier function. Some studies suggest that the nasal mucosa of patients with chronic rhinosinusitis is also involved in the destruction of epithelial cell barrier function and the change of tight junction associated protein expression. The purpose of this article is to review the damage of nasal mucosal epithelial barrier function and the changes of tight junction protein expression in chronic rhinosinusitis and allergic rhinitis. This paper attempts to further study the pathogenesis of chronic rhinosinusitis and allergic rhinitis from the function of nasal epithelial barrier.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R765.21

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