异种脱细胞真皮基质在结膜囊成形术中的应用

发布时间：2018-05-13 02:39

本文选题：异种脱细胞真皮基质 + 睑球粘连　；参考：《眼科新进展》2017年01期

【摘要】：目的观察在治疗睑球粘连、结膜囊狭窄等结膜囊成形术中应用异种脱细胞真皮基质的临床疗效。方法对2012年1月至2016年1月我科收治的睑球粘连患者13例(13眼)和结膜囊狭窄患者63例(63眼),共76例(76眼)行粘连分离加异种脱细胞真皮基质移植术,术后随访6~12个月,观察手术效果。结果术后1个月,异种脱细胞真皮基质贴附良好,新生结膜爬行其上,睑球无粘连,结膜囊成形良好,总有效率100%(76/76)。术后40 d至2个月,异种脱细胞真皮基质溶解吸收后,3例(碱烧伤2例,重度沙眼1例)睑球粘连患者,重新出现睑球粘连,5例重度结膜囊狭窄伴眼睑外翻重新出现结膜囊狭窄、睑外翻均于3个月后再次行粘连分离+异种脱细胞真皮基质移植术,效果良好;其余68例术后2个月异种脱细胞真皮基质完全溶解吸收,睑球无粘连,结膜囊成形良好,总有效率89.5%(68/76)。随访6~12个月,76例患者均达到满意效果,无复发。结论异种脱细胞真皮基质是一种新的、良好的眼结膜替代生物膜,可以用于结膜囊成形手术。
[Abstract]:Objective to observe the clinical effect of xenogeneic acellular dermal matrix in the treatment of blepharoconjunctival adhesion and conjunctival sac stenosis. Methods from January 2012 to January 2016, 13 cases (13 eyes) with blepharoconjunctival adhesion and 63 cases (76 eyes) with conjunctival sac stenosis were treated with adhesions separation and xenogeneic acellular dermal matrix transplantation. The follow-up was 6 ~ 12 months. To observe the effect of operation. Results one month after operation, the xenogeneic acellular dermal matrix was attached well, the new conjunctiva crawled on it, the eyelid ball was not conglutinated, the conjunctival sac was well formed, and the total effective rate was 100 / 76 / 76. From 40 days to 2 months after operation, 3 cases (2 cases of alkali burn, 1 case of severe trachoma) with symblepharon were treated with acellular dermatolysis and absorption of xenogeneic acellular dermal matrix. There were 5 cases of severe conjunctival sac stenosis and ectropion conjunctival sac stenosis again. In the remaining 68 cases, the xenoacellular dermal matrix was completely dissolved and absorbed 2 months after operation, there was no symblepharon, the conjunctival sac was well formed, and the total effective rate was 89. 5% / 76%. All the 76 patients were followed up for 6 ~ 12 months with satisfactory results and no recurrence. Conclusion xenogeneic acellular dermal matrix is a new and good substitute biofilm for conjunctiva and can be used in conjunctival sac formation.
【作者单位】：南昌大学第二附属医院眼科;
【分类号】：R779.6

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