MAGE-A3在鼻咽癌的表达及意义

发布时间：2018-05-19 03:42

本文选题：MAGE-A3 + 鼻咽癌　；参考：《广西医科大学》2012年硕士论文

【摘要】：目的：了解癌-睾丸抗原(cancer-testis antigen, CTA)----黑色素瘤抗原-A3(Melanoma antigen A3,MAGE-A3)在鼻咽癌(nasopharyngeal carcinoma, NPC)组织中的表达情况,探讨MAGE-A3抗原用于NPC免疫诊断标记及其免疫治疗的可行性。方法：采用免疫组织化学S-P法检测51例经病理确诊的NPC组织和20例鼻咽部粘膜慢性炎症(鼻炎)组织中MAGE-A3的表达情况,检测结果用SPSS13.0统计学软件包进行处理,并分析其表达率与临床指标之间的关系。结果：(1) MAGE-A3在NPC中的阳性表达率为64.71%(33/51),在鼻咽部粘膜慢性炎症(鼻炎)组织中只有两例呈弱阳性,表达率仅为10%；(2)实验组与对照组之间的表达差异有统计学意义(P0.01)；(3)MAGE-A3的表达与NPC患者临床指标(性别、年龄、疾病的临床分期、有无淋巴结转移)之间无相关性(P0.05)。结论：MAGE-A3在NPC中呈较高表达,提示MAGE-A3有作为靶抗原的可能用于NPC免疫诊断和治疗。
[Abstract]:Objective: to investigate the expression of cancer-testis antigenin (CTA-testicular antigen) in nasopharyngeal carcinoma (NPC) tissues, and to explore the feasibility of using MAGE-A3 antigen in the diagnosis of NPC and its immunotherapy. Methods: immunohistochemical S-P method was used to detect the expression of MAGE-A3 in 51 cases of pathologically diagnosed NPC and 20 cases of nasopharyngeal mucosa chronic inflammation (rhinitis). The results were processed by SPSS13.0 statistical software package. The relationship between the expression rate and clinical indexes was analyzed. Results the positive expression rate of MAGE-A3 in NPC was 64.71g / 51g, and only two cases were weakly positive in nasopharyngeal mucosa chronic inflammation (rhinitis). There was no correlation between the expression of MAGE-A3 and the clinical indexes (sex, age, clinical stage of disease, lymph node metastasis or not) between the experimental group and the control group (P 0.01), and there was no correlation between the expression of MAGE-A3 and the clinical indexes (sex, age, clinical stage of disease, lymph node metastasis or not). Conclusion the high expression of VMAGE-A3 in NPC suggests that MAGE-A3 may be used as a target antigen for immunologic diagnosis and treatment of NPC.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R739.63

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