新疆维吾尔人群两种变应原检测方法对比研究

发布时间：2018-05-19 16:06

本文选题：维吾尔族 + 变应性鼻炎　；参考：《新疆医科大学》2012年硕士论文

【摘要】：目的：探讨新疆地区针对维吾尔族人群体内变应原皮试（采用阿罗格点刺实验）和体外特异性IgE检测应用（IVT ALLergen Screenf方法）的临床价值。方法：采用花粉变应原浸液对81例变应性鼻炎(AR)花粉症患者作过敏原皮试检查;同时进行血清特异性I gE含量的测定。结果：81例花粉变应原皮试阳性患者血清特异IgE明显异常,以变应原皮试为对照，特异性IgE检测的灵敏度在86.67%～97.87%，，特异度在88.24%～94.34%，两种检查方法的总阳性率34.57%～62.97%,阳性一致率88.89%～95.06%,皮肤点刺阳性率28.40%～58.02%，体外特异性IgE检测阳性率32.10%～61.73%，差异有显著性(P 0.05～0.005)，相关系数0.765～0.845，Kappa值在0.525～0.621%。结论：表明两种检测方法的抗原特异性高度一致,体外特异性IgE检测的阳性率稍高于变应原皮试，两种检测方法对于明确维吾尔族AR患者特异性抗体、病因诊断、脱敏治疗中均有重要的临床意义。
[Abstract]:Objective: to investigate the clinical value of allergen skin test (Arroge prick test) and in vitro specific IgE assay (IVT ALLergen Screenf method) in Xinjiang Uygur population. Methods: 81 cases of allergic rhinitis were examined with pollen allergen extract and serum specific IgE content was determined. Results Serum specific IgE was significantly abnormal in 81 patients with positive pollen allergen skin test, and the allergen skin test was used as control. The sensitivity of specific IgE was 86.67 and 97.87, and the specificity was 88.240.34. The total positive rate of the two methods was 34.575.97. The positive rate was 88.890.95.06. the positive rate of skin prick was 28.400.577.The positive rate of in vitro specific IgE was 32.1061.73.The difference was significant (P 0.05), and the correlation coefficient was 0.7650.845kappa was 0.525250.21. Conclusion: the antigen-specificity of the two methods is highly consistent, and the positive rate of in vitro specific IgE detection is slightly higher than that of allergen skin test. The two methods are useful for the determination of specific antibodies and etiological diagnosis of Uygur AR patients. Desensitization therapy has important clinical significance.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R765.21

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