微小染色体维持蛋白7在鼻腔鼻窦鳞状细胞癌中的表达及临床意义的研究

发布时间：2018-05-19 16:53

  本文选题：微小染色体维持蛋白 + 鼻腔鼻窦　； 参考：《中国医科大学学报》2017年04期

【摘要】：目的检测微小染色体维持蛋白7(MCM7)在鼻腔鼻窦鳞状细胞癌(SNSCC)中的表达水平,分析其与肿瘤组织分化程度及患者预后的关系。方法采用免疫组化法检测SNSCC和慢性鼻窦炎鼻息肉(NPCRS)中MCM7的表达情况,并分析其与临床病理特征的关系。结果 NPCRS中,MCM7阳性细胞主要分布于上皮基底层,且表达率较低。SNSCC中,MCM7阳性细胞呈弥漫性分布,且表达率较高。MCM7在SNSCC中的表达水平高于NPCRS,差异有统计学意义(P0.001)。MCM7的表达仅与肿瘤分化程度有关(P=0.001),且随着分化程度的下降而逐渐增高。SNSCC患者总体3年和5年生存率分别为61.3%和46.0%。Ⅰ~Ⅲ期和Ⅳ期患者的3年生存率分别为90.0%和25.6%,5年生存率分别为70.0%和17.1%,差异有统计学意义(P0.001)。MCM7阴性患者3年、5年生存率为36.0%和18.0%,而阳性患者3年、5年生存率为59.9%和34.2%,差异无统计学意义(P=0.297)。结论MCM7在SNSCC中表达水平显著升高,而且与肿瘤分化程度有关,随着肿瘤分化程度下降,MCM7表达水平逐渐增高,但与SNSCC患者的生存率无关。
[Abstract]:Objective to detect the expression of MCM7 in squamous cell carcinoma of nasal cavity and paranasal sinuses (SNSCC), and to analyze the relationship between the expression of MCM7 and the differentiation of tumor tissue and the prognosis of patients with squamous cell carcinoma of nasal cavity and paranasal sinuses. Methods Immunohistochemical method was used to detect the expression of MCM7 in SNSCC and chronic sinusitis and nasal polyp (NPCRSs), and the relationship between MCM7 expression and clinicopathological features was analyzed. Results the positive cells of MCM7 in NPCRS were mainly distributed in the basal layer of epithelium, and the expression rate was low. MCM7 positive cells were distributed diffusely in NPCRS. The expression level of .MCM7 in SNSCC was higher than that in NPCRSs. The difference was statistically significant. The expression of MCM7 was only related to the degree of tumor differentiation, and the overall 3-year and 5-year survival rate was increased with the decrease of differentiation degree. The 3-year survival rate was 90.0% and 25.6% in stage 鈪，

本文编号：1910898