布地奈德盐水鼻腔冲洗治疗儿童鼻-鼻窦炎疗效分析

发布时间：2018-05-21 19:46

本文选题：鼻腔冲洗 + 鼻窦炎　；参考：《临床耳鼻咽喉头颈外科杂志》2016年12期

【摘要】：目的:研究鼻腔冲洗对儿童鼻-鼻窦炎的临床疗效,并比较鼻腔冲洗与传统鼻用激素治疗以及不同冲洗方法间的疗效差异。方法:将75例鼻-鼻窦炎患儿随机分为生理盐水组(20例)、布地奈德组(20例)、布地奈德-生理盐水组(20例)和高渗盐水组(15例),于治疗前及治疗后1周、2周,对所有患儿的黏液纤毛清除时间、鼻腔情况评分及生活质量评分进行评估分析。结果:治疗后各组的糖精清除时间、鼻腔情况评分、生活质量评分均较治疗前好转,差异有统计学意义。各组之间疗效比较,布地奈德-生理盐水组最优,以下依次为布地奈德组、高渗盐水组、生理盐水组,且各组之间的差异均有统计学意义。结论:鼻腔冲洗对鼻-鼻窦炎患儿具有明确疗效。单独使用盐水鼻腔冲洗的疗效不及布地奈德鼻喷雾剂的局部使用,在鼻腔冲洗液中加用布地奈德混悬液可起到效果叠加的作用,使疗效更为突出。
[Abstract]:Objective: to study the clinical efficacy of nasal irrigation in children with rhinosinusitis, and to compare the curative effect between nasal lavage and traditional nasal hormone therapy. Methods: 75 children with nasosinusitis were randomly divided into normal saline group (n = 20), budesonide group (n = 20) and hypertonic saline group (n = 15). The mucociliary clearance time, nasal condition score and quality of life score were evaluated and analyzed in all children. Results: after treatment, saccharin clearance time, nasal cavity score and quality of life score were better than those before treatment, and the difference was statistically significant. Among the groups, budesonide-physiological saline group was the best, followed by budesonide group, hypertonic saline group, physiological saline group, and the differences among the groups were statistically significant. Conclusion: nasal irrigation has definite curative effect on children with rhinosinusitis. The effect of brine nasal lavage alone is not as good as that of budesonide nasal spray. Adding budesonide suspension to nasal lavage fluid can play a superposition effect and make the curative effect more prominent.
【作者单位】：首都医科大学附属北京儿童医院耳鼻咽喉科儿童耳鼻咽喉头颈外科疾病北京市重点实验室;
【基金】：首发基金(No:2009-1035) 北京市教育委员会科技计划面上项目(No:KM201410025021)
【分类号】：R765.41

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