鼻咽癌患者外周血共刺激分子的表达水平及其临床意义

发布时间：2018-05-24 16:34

  本文选题：鼻咽癌 + 共刺激分子　； 参考：《中国肿瘤生物治疗杂志》2017年07期

【摘要】：目的:检测鼻咽癌患者外周血中T细胞表面程序性死亡分子1(programmed death-1,PD-1)、刺激分子4-1BB的表达水平,探讨其在鼻咽癌中的临床意义。方法:选取2016年10至11月福建省肿瘤医院病理确诊的鼻咽癌患者30例作为研究对象,并选取同期本院体检中心性别、年龄相近的健康体检者30例作为对照组。通过流式细胞术检测外周血T细胞表面PD-1、4-1BB的表达情况以及T淋巴细胞亚群的比例。核磁共振扫描测量原发肿瘤体积。结果:鼻咽癌Ⅲ期患者外周血CD8+T细胞比例明显低于Ⅳ期患者[(13.1±6.2)%vs(18.7±5.5)%,P0.05]。与对照组相比,CD4+T细胞上PD-1阳性表达率显著上调[(8.7±6.5)%vs(3.87±3.0)%,P0.05]。鼻咽癌患者外周血T细胞PD-1、4-1BB分子表达水平与临床分期、肿瘤负荷、性别及年龄无显著相关(P0.05)。结论:鼻咽癌患者外周血PD-1和4-1BB两种共刺激分子在患者体内肿瘤免疫逃逸中可能存在协同效应。联合干预这两种共刺激分子的信号通路可能具有更高效持久的抗肿瘤效应,可为鼻咽癌免疫治疗提供新的思路。
[Abstract]:Objective: to detect the expression of 1(programmed death-1 PD-1 and stimulator 4-1BB in peripheral blood of patients with nasopharyngeal carcinoma (NPC), and to explore its clinical significance. Methods: thirty patients with nasopharyngeal carcinoma (NPC) confirmed by pathology in Fujian Cancer Hospital from October to November 2016 were selected as the study object, and 30 healthy persons with similar age and sex were selected as the control group. The expression of PD-1 4-1BB on peripheral T cells and the proportion of T lymphocyte subsets were detected by flow cytometry. The volume of primary tumor was measured by MRI. Results: the percentage of CD8 T cells in patients with NPC stage 鈪，

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