普拉洛芬滴眼液和氟米龙滴眼液治疗中重度干眼症的疗效比较

发布时间：2018-05-24 17:51

本文选题：干眼症 + 普拉洛芬滴眼液　；参考：《今日药学》2016年07期

【摘要】：目的比较0.1%普拉洛芬滴眼液和0.1%氟米龙滴眼液治疗中重度干眼症的疗效。方法前瞻性随机对照研究。对中重度干眼症的患者共21人39只眼随机分配成2组:试验组11人20只眼,给予0.1%普拉洛芬滴眼液和0.1%玻璃酸钠滴眼液联合用药;对照组10人19只眼使用0.1%氟米龙滴眼液和0.1%玻璃酸钠滴眼液。用药前、用药7 d时分别进行主观问卷调查和泪膜破裂时间(BUT)检测。结果试验组和对照组年龄及性别构成无统计学意义(P0.05)。试验组和对照组用药前平均BUT分别为(2.30±0.92)s、(2.21±0.97)s,2组用药前平均BUT差别无统计学意义(t=0.294,P=0.77)。用药1周后试验组和对照组的平均BUT分别为(5.25±2.95)s、(2.63±1.54)s,2组用药后1周平均BUT差别有统计学意义(P=0.002)。试验组和对照组治疗前后的BUT变化幅度有统计学差别(F=13.76,P=0.001),试验组用药1周的BUT上升幅度明显大于对照组。2组患者用药前和用药后1周的主观问卷调查分值无统计学差异。结论 0.1%普拉洛芬滴眼液联合0.1%玻璃酸钠滴眼液组治疗中重度干眼症的早期疗效显著,优于0.1%氟米龙滴眼液联合0.1%玻璃酸钠滴眼液。
[Abstract]:Objective to compare the efficacy of 0.1% Praprofen eye drops and 0.1% flumilon eye drops in the treatment of moderate and severe xerophthalmia. Methods A prospective randomized controlled study was conducted. Twenty-one patients (39 eyes) with moderate and severe xerophthalmia were randomly divided into two groups: the experimental group (n = 11, n = 20) was treated with 0.1% Praprofen eye drops and 0.1% sodium hyaluronate eye drops; The control group was treated with 0.1% flumilon eye drops and 0.1% sodium hyaluronate eye drops. Before and 7 days after administration, subjective questionnaire and tear film rupture time were measured. Results there was no significant difference in age and sex composition between the experimental group and the control group (P 0.05). The average BUT of the test group and the control group was 2.30 卤0.92 BUT before the treatment, respectively. There was no significant difference in the average BUT between the two groups before the treatment. There was no significant difference between the two groups. The average BUT of the test group and the control group were 5.25 卤2.95 BUT and 2.63 卤1.54 BUT respectively after one week of administration. There was significant difference in the average BUT between the two groups. There was significant difference in the range of BUT between the experimental group and the control group before and after treatment. The increase of BUT in the test group was significantly higher than that in the control group before and after 1 week treatment. There was no significant difference in the score of subjective questionnaire survey between the two groups. Conclusion 0.1% Praprofen eye drops combined with 0.1% sodium hyaluronate eye drops have significant early therapeutic effect on moderate and severe xerophthalmia, which is superior to 0.1% flumilon eye drops combined with 0.1% sodium hyaluronate eye drops.
【作者单位】：汕头大学.香港中文大学联合汕头国际眼科中心;
【基金】：广东省临床用药研究基金(2015RL11)
【分类号】：R777.34

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