那他霉素联合伊曲康唑治疗真菌性角膜炎的疗效分析

发布时间：2018-05-27 08:12

本文选题：那他霉素滴眼液 + 伊曲康唑胶囊　；参考：《中国现代医学杂志》2017年20期

【摘要】：目的观察那他霉素滴眼液联合伊曲康唑胶囊治疗真菌性角膜炎的临床疗效。方法选取2014年3月-2016年5月浙江省宁波市眼科医院收治的真菌性角膜炎患者92例,随机分为观察组(那他霉素滴眼液+伊曲康唑胶囊)和对照组(那他霉素滴眼液),两组患者治疗14 d后对比临床疗效、治疗前后角膜染色、共聚焦角膜显微镜等,并记录与治疗相关不良反应发生情况。结果观察组临床治疗总有效率为86.96%、对照组为63.04%,观察组高于对照组(P0.05)。观察组治疗后角膜染色阳性率为13.04%、对照组为36.96%,观察组低于对照组(P0.05)。结论对于真菌性角膜炎患者在局部使用那他霉素滴眼液基础上,配合口服伊曲唑康胶囊能够提高临床疗效,用药方便,值得临床推广应用。
[Abstract]:Objective to observe the clinical effect of natamycin eye drops combined with itraconazole capsule in the treatment of fungal keratitis. Methods from March 2014 to May 2016, 92 patients with fungal keratitis were selected from Ningbo Eye Hospital of Zhejiang Province. They were randomly divided into observation group (natamycin eye drops and itraconazole capsules) and control group (natamycin eye drops). The clinical effects of the two groups were compared after 14 days of treatment, corneal staining before and after treatment, confocal corneal microscope, etc. Adverse reactions related to treatment were recorded. Results the total effective rate of clinical treatment was 86.96 in the observation group and 63.04 in the control group, which was higher in the observation group than in the control group. The positive rate of corneal staining was 13.04 in the observation group and 36.96 in the control group, which was lower than that in the control group. Conclusion on the basis of topical application of natamycin eye drops for patients with fungal keratitis, combined with oral itraconazole capsule can improve the clinical efficacy and is convenient to use, and it is worth popularizing and applying.
【作者单位】：浙江省宁波市眼科医院眼科;浙江大学医学院附属邵逸夫医院眼科;
【基金】：2014年浙江省医药卫生一般研究计划项目(No:2014KYB131)
【分类号】：R772.21

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