荷丹片联合阿托伐他汀对伴有睡眠呼吸暂停的脑梗死患者血脂及炎症因子的影响

发布时间：2018-05-27 08:46

  本文选题：荷丹片 + 阿托伐他汀　； 参考：《中国医药导报》2016年03期

【摘要】：目的探讨荷丹片联合阿托伐他汀对伴有睡眠呼吸暂停的脑梗死患者血脂及炎症因子的影响。方法依据多导睡眠图检测结果选取2013年1月~2015年6月于河北大学附属医院就诊的74例伴有睡眠呼吸暂停的脑梗死患者作为研究对象,随机分为对照组和观察组,两组均为37例,对照组给予口服阿托伐他汀,观察组给予口服荷丹片联合阿托伐他汀,两组患者均给药4周,观察治疗前后血清三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、超敏C反应蛋白(hs-CRP)及可溶性细胞间黏附分子1(s ICAM-1)的变化情况。结果观察组及对照组患者治疗后血清TG[(2.549±0.441)、(2.854±0.444)mmol/L]、TC[(2.865±1.035)、(2.992±0.991)mmol/L]、LDL-C[(1.778±0.486)、(1.827±0.527)mmol/L]、hs-CRP[(1.846±0.607)、(2.230±0.799)mg/L]及s ICAM-1[(315.532±39.717)、(345.108±30.733)ng/m L]水平均较治疗前[(3.630±0.548)、(3.862±0.683)mmol/L;(5.878±0.999)、(5.757±1.062)mmol/L;(3.687±0.581)、(3.538±0.658)mmol/L;(4.500±1.432)、(4.422±1.540)mg/L;(397.762±33.752)、(409.243±39.001)ng/m L]显著降低,差异有高度统计学意义(P0.01)。两组治疗后TC、LDL-C水平比较差异无统计学意义(P0.05),但观察组治疗后TG、hs-CRP及s ICAM-1水平显著低于对照组,差异有统计学意义(P0.05或P0.01)。结论荷丹片联合阿托伐他汀对伴有睡眠呼吸暂停的脑梗死患者有较强的降脂作用,尤其是降TG方面,且增强抗炎作用。
[Abstract]:Objective to investigate the effects of Hedan tablets combined with Atto vastatin on blood lipid and inflammatory factors in patients with cerebral infarction with sleep apnea. Methods according to the results of polysomnography, 74 patients with cerebral infarction with sleep apnea were randomly divided into control group and observation group from January 2013 to June 2015. The control group was given Atto vastatin and the observation group was treated with Hedan tablet combined with Atto vastatin for 4 weeks. The changes of serum triacylglycerol (TGG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), hypersensitive C-reactive protein (hs-CRP) and soluble intercellular adhesion molecule (ICAM-1) were observed before and after treatment. 缁撴灉瑙傚療缁勫強瀵圭収缁勬偅鑰呮不鐤楀悗琛，

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