糠酸莫米松鼻喷剂联合孟鲁司特钠治疗儿童腺样体肥大的疗效观察

发布时间：2018-05-27 23:33

本文选题：糠酸莫米松 + 孟鲁司特钠　；参考：《临床耳鼻咽喉头颈外科杂志》2017年05期

【摘要】：目的:研究糠酸莫米松鼻喷剂联合孟鲁司特钠治疗儿童腺样体肥大的临床效果。方法:将138例腺样体肥大患儿随机分为2组,每组各69例,对照组单独使用糠酸莫米松鼻喷剂进行治疗,观察组在糠酸莫米松鼻喷剂治疗基础上联用孟鲁司特钠口服进行治疗。比较2组患儿治疗前后的腺样体鼻咽腔比例(A/N),治疗后患儿鼻塞、打鼾、张口呼吸的比例及整体复发率,治疗前后的生活质量评分,最后比较临床总有效率。结果:与治疗前比较,2组患儿治疗后的A/N均明显降低,且观察组下降更明显(P0.05);治疗后,观察组患儿鼻塞、打鼾、张口呼吸的发生率均明显低于对照组,且整体复发率也低于对照组(P0.05);在生活质量评分比较中,2组患儿治疗后的睡眠障碍评分、身体状态评分以及日常功能评分与治疗前比较,均明显下降,且观察组患儿上述3项评分下降更为明显(P0.05);观察组临床总有效率可达94.1%,明显高于对照组的79.4%(P0.05)。结论:糠酸莫米松鼻喷剂联合孟鲁司特钠治疗儿童腺样体肥大的临床效果显著,可以有效降低A/N,改善患儿的打鼾、张口呼吸、鼻塞症状,提高患儿的生活质量,临床有效率更高,好于单一药物治疗,值得推广。
[Abstract]:Objective: to study the clinical effect of momethasone furoate nasal spray combined with montelukast sodium in the treatment of adenoid hypertrophy in children. Methods: 138 children with adenoid hypertrophy were randomly divided into two groups (69 cases in each group). The control group was treated with momethasone furoate nasal spray alone, and the observation group was treated with montelukast sodium on the basis of momethasone furoate nasal spray. The ratio of adenoid nasopharynx before and after treatment was compared between the two groups. After treatment, the proportion of nasal obstruction, snoring, open mouth breathing and overall recurrence rate, the quality of life score before and after treatment were compared, and the total clinical effective rate was compared. Results: compared with those before treatment, the incidence of nasal congestion, snoring and open mouth breathing in the observation group was significantly lower than that in the control group, and the decrease was more obvious in the observation group than that in the control group after the treatment, and the incidence of nasal congestion, snoring and open mouth breathing was significantly lower in the observation group than in the control group. The overall recurrence rate was also lower than that in the control group (P 0.05), and the scores of sleep disorder, body status and daily function in the control group were significantly lower than those before treatment, and the scores of sleep disorder, body status and daily function in the control group were significantly lower than those before treatment. The clinical effective rate of the observation group was 94.1, which was significantly higher than that of the control group (P 0.05). Conclusion: the clinical effect of momethasone furoate nasal spray combined with montelukast sodium in the treatment of children with adenoid hypertrophy is remarkable. It can effectively reduce A- N, improve snoring, open mouth breathing, nasal congestion, and improve the quality of life of children. The clinical effective rate is higher, is better than the single drug treatment, is worth popularizing.
【作者单位】：南京医科大学第二附属医院耳鼻咽喉头颈外科;
【分类号】：R766

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