OSAHS患者HCY、SAA水平与认知功能的关系研究

发布时间：2018-05-29 17:54

本文选题：阻塞性睡眠呼吸暂停低通气综合征 + 蒙特利尔认知评估量表　；参考：《中国现代医学杂志》2017年01期

【摘要】：目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者同型半胱氨酸(HCY)、淀粉样蛋白A(SAA)水平与认知功能的关系。方法测定62例OSAHS患者及同期37例健康体检者(对照组)的HCY、SAA水平,并依据蒙特利尔认知评估量表(Mo CA)进行评分,分析HCY、SAA与认知结果的相关性。结果 1OSAHS患者HCY、SAA水平[分别为(13.60±3.00)和(105.32±34.63)μmol/L]高于对照组[(11.21±1.10)和(44.72±48.3)μmol/L],差异有统计学意义,其Mo CA总分及立方体构图、画钟试验、目标数字识别、延迟回忆亚项评分低于对照组,差异有统计学意义(P0.05);2OSAHS组SAA、HCY水平与Mo CA总分呈负相关(rHCY=-0.475,rSAA=-0.767,P=0.000);3OSAHS患者合并轻度认知障碍,HCY、SAA[分别为(12.99±2.90)和(85.19±50.08)μmol/L]水平较正常认知组[分别为(11.56±0.70)和(52.12±10.40)μmol/L]升高,差异有统计学意义(P0.05);4受试者工作特征曲线分析OSAHS患者认知功能障碍的HCY、SAA曲线下面积分别为0.77和0.72。结论HCY、SAA是OSAHS患者认知功能障碍形成的影响因素,其水平与认知损害程度呈负相关。
[Abstract]:Objective to investigate the relationship between the level of homocysteine (HCY) and amyloid (Alosa) and cognitive function in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods the levels of HCYTSAA were measured in 62 patients with OSAHS and 37 healthy controls (control group), and their correlation with cognitive results were analyzed according to the Montreal Cognitive Assessment scale (MCAA). Results the levels of 1OSAHS in 1OSAHS patients (13.60 卤3.00) and 105.32 卤34.63 渭 mol/L were significantly higher than those in the control group [11.21 卤1.10) and 44.72 卤48.3 渭 mol/L]. The total score of Mo CA, cube composition, clock drawing test, target number recognition and delayed recall subitem score were lower than those in the control group. There was a negative correlation between the level of mol/L and the total score of Mo CA in patients with P0.05 and 22OSAHS. The levels of mol/L in patients with mild cognitive impairment were significantly higher than those in the normal group [11.56 卤0.70 and 52.12 卤10.40 渭 mol/L, respectively, respectively], and the levels of mol/L in patients with mild cognitive impairment were significantly higher than those in the normal cognitive group [11.56 卤0.70 and 52.12 卤10.40 渭 mol/L, respectively], and there was no significant difference between the two groups (P < 0.01, P > 0.05, P > 0.05, P < 0.05), and the level of HCY was negatively correlated with the total score of Mo CA in the patients with mild cognitive impairment (12.99 卤2.90) and 85.19 卤50.08 渭 mol/L, respectively. The difference was statistically significant (P 0.05). The area under the OSAHS cognitive dysfunction curve was 0.77 and 0.72, respectively. Conclusion HCYA SAA is an influential factor of cognitive impairment in OSAHS patients, and its level is negatively correlated with the degree of cognitive impairment.
【作者单位】：华北理工大学附属医院呼吸科;
【基金】：2016年度河北省医学科学研究重点课题计划(No:20160221) 河北省省级重大医学科研课题(No:ZD2013091)
【分类号】：R766

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