复方苦参注射液治疗局部晚期鼻咽癌同期放化疗所致急性口腔黏膜损伤的疗效

发布时间：2018-05-30 04:07

本文选题：复方苦参注射液 + 鼻咽癌　；参考：《现代肿瘤医学》2016年12期

【摘要】：目的:观察复方苦参注射液治疗局部晚期鼻咽癌同期放化疗所致口腔黏膜损伤的疗效。方法:将82例局部晚期鼻咽癌患者随机分为两组,治疗组42例,对照组40例,两组化疗方案均采用顺铂三周方案并同步调强放射治疗(intensity modulated radiation therapy,IMRT)。治疗组应用复方苦参注射液联合生理盐水、利多卡因、庆大霉素和地塞米松配制的含漱液及复方硼砂溶液漱口,对照组应用生理盐水、利多卡因、庆大霉素和地塞米松配制的含漱液及复方硼砂溶液漱口,观察并比较两组病人治疗急性口腔黏膜损伤的效果。结果:所有患者均完成了放疗计划,治疗组在放疗第4周末及放疗结束时急性口腔黏膜的损伤程度明显低于对照组(P均0.05);治疗组口腔黏膜损伤引起的疼痛程度低于对照组(P0.05);比较两组治疗前后患者的体质量下降值,治疗组平均体质量下降明显低于对照组(P0.01);并且治疗组平均总放疗时间少于对照组(P0.01)。结论:复方苦参注射液治疗局部晚期鼻咽癌同期放化疗所致急性口腔黏膜损伤效果明显,值得临床推广应用。
[Abstract]:Objective: to observe the efficacy of compound Sophora flavescens injection in the treatment of oral mucosal injury caused by radiotherapy and chemotherapy in local advanced nasopharyngeal carcinoma. Methods: 82 patients with locally advanced nasopharyngeal carcinoma were randomly divided into two groups: treatment group (n = 42) and control group (n = 40). The treatment group was gargled with compound Sophora flavescens injection combined with saline, lidocaine, gentamicin and dexamethasone, while the control group was gargled with normal saline and lidocaine. Gentamicin and dexamethasone gargle containing gargle and compound borax solution were used to observe and compare the efficacy of the two groups in the treatment of acute oral mucosal injury. Results: all patients completed the radiotherapy program. The degree of acute oral mucosal injury in the treatment group was significantly lower than that in the control group at the end of the 4th week of radiotherapy and at the end of radiotherapy, and the degree of pain caused by oral mucosal injury in the treatment group was lower than that in the control group (P 0.05). The mean body mass in the treatment group was significantly lower than that in the control group (P 0.01), and the average total radiotherapy time in the treatment group was less than that in the control group (P 0.01). Conclusion: compound Sophora flavescens injection is effective in treating acute oral mucosal injury caused by radiotherapy and chemotherapy of local advanced nasopharyngeal carcinoma.
【作者单位】：西安交通大学医学院第二附属医院肿瘤科;
【分类号】：R739.63

【相似文献】