前部缺血性视神经病变的综合治疗临床观察

发布时间：2018-05-31 05:57

本文选题：视神经病变 + 缺血性　；参考：《山西医科大学》2016年硕士论文

【摘要】：目的:观察综合治疗对前部缺血性视神经病变的临床疗效。方法:收集2014年1月到2015年6月来山西医科大学第一医院就诊的前部缺血性视神经病变患者40例(42眼)作为研究对象。所有患者均积极治疗全身疾病,同时全身及局部给予激素、扩血管、神经营养药物以及颞浅动脉旁注射复方樟柳碱等综合治疗,一个疗程15天,随访30~45天。结果:40例(42眼)患者中,女15例,男25例;其中10例伴有糖尿病、24例伴高血压病、22例伴高血脂症,18例患者有吸烟史。40例患者的发病年龄为42~71岁,平均为55.52岁,病程为2天~1个月,平均11.48天。40例(42眼)患者治疗15天后视力有显著提高(P0.01),随访观察30~45天后视力较治疗15天时提高(P=0.029);治疗前平均视野缺损值为16.14±5.05dB,治疗15天后平均视野缺损值为11.56±3.74dB,明显降低(t=12.63,P0.01),随访观察30~45天时平均视野缺损值9.53±3.89dB,较治疗15天时降低(t=8.94,P0.01);随访观察30~45天后总有效率(90.48%)与治疗15天时总有效率(78.57%)比较P=0.113,尚不能认为差异有统计学意义。结论:综合治疗前部缺血性视神经病变的临床疗效显著,能有效提高患眼视力,降低视野缺损,明显减轻视乳头水肿程度。
[Abstract]:Objective: to observe the clinical effect of comprehensive treatment on anterior ischemic optic neuropathy. Methods: from January 2014 to June 2015, 40 patients (42 eyes) with anterior ischemic optic neuropathy from the first Hospital of Shanxi Medical University were selected as the study objects. All the patients were treated actively with systemic diseases. At the same time, the patients were given hormone, vasodilator, neurotrophic drugs and compound anisodine injection by the superficial temporal artery. The course of treatment was 15 days, and the follow-up was 30 days and 45 days. Results among 40 cases, 15 cases were female and 25 cases were male, among them 10 cases were accompanied with diabetes mellitus, 24 cases with hypertension, 22 cases with hyperlipidemia, 18 cases with smoking history and 40 cases with smoking history. The age of onset was 42 or 71 years, with an average age of 55.52 years. The course of disease ranged from 2 days to 1 month. The visual acuity of the patients increased significantly after 15 days of treatment. The visual acuity after 30 days 45 days was higher than that of 15 days after treatment, the average visual field defect before treatment was 16.14 卤5.05 dB, the average visual field defect value after 15 days treatment was 11.56 卤3.74 dB, and the average visual field defect was 11.56 卤3.74 dB after 15 days. The mean visual field defect value was 9.53 卤3.89 dB at 30 ~ 45 days, which was lower than that at 15 days after treatment, and the total effective rate was 90.48 days after 30 ~ 45 days (P = 0.113) compared with that at 15 days after treatment (P = 0.113). Conclusion: comprehensive treatment of anterior ischemic optic neuropathy is effective in improving visual acuity, reducing visual field defect and reducing the degree of papillary edema.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R774.6

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