鼻用糖皮质激素对变应性鼻炎患者肺功能的影响

发布时间：2018-06-01 02:47

  本文选题：变应性鼻炎 + 布地奈德　； 参考：《青岛大学》2016年硕士论文

【摘要】：目的:1.观察变应性鼻炎患者肺功能变化;2.鼻用糖皮质激素对于变应性鼻炎患者肺功能的影响。方法:选择90名中重度AR患者和50名正常对照组进行肺功能检查,90名AR患者分为A组(50人)和B组(40人)两组,A组鼻用布地奈德加氯雷他定口服,B组鼻用生理海水加氯雷他定口服,3个月治疗后,A组结果记为C组,B组结果记为D组,再次进行肺功能检查并进行对比检验。结果:AR组与正常对照组:FEV1.0/FVC,MMF,FEF50%,FEF75%比较差异具有显著性(P0.01);AR组无通气功能异常,小气道功能异常51例,占56.7%,对照组通气功能均正常,小气道异常14例,占28.0%。χ2=11.5(P0.01),两者对比差异具有显著统计意义。A组用药三个月后与用药前(即C组与A组)对比:FEV1.0/FVC(P0.05),MMF,FEF50%,FEF75%(P0.01)差异具有显著性;A组与B组用药后结果对比(即C组与D组):FEF75%(P0.05);C组与正常对照组对比无差异;B组用药三个月后与用药前对比(即D组对B组):MMF,FEF75%(P0.05);D组与正常对照组对比FEF75%(P0.05)。结论:变应性鼻炎患者的部分肺功能指标降低,主要表现为小气道功能受损,鼻用糖皮质激比氯雷他定更能有效地改善患者的肺功能。
[Abstract]:Purpose 1. To observe the changes of pulmonary function in patients with allergic rhinitis. Effects of nasal glucocorticoid on pulmonary function in allergic rhinitis. Methods: 90 patients with moderate and severe AR and 50 normal controls were divided into two groups: group A (n = 50) and group B (n = 40). After 3 months of treatment, the results of group A were recorded as group C and group B were recorded as group D. Pulmonary function test and contrast test were performed again. Results there was no abnormal ventilatory function and 51 cases with abnormal small airway function (56.7%) in the control group (P < 0.01). The ventilation function of the control group was normal and the small airway was abnormal in 14 cases, and there was no abnormal ventilation function in the control group compared with that in the normal control group (FEV 1.0 / FVCU / FEF50%), and there was no abnormality in the small airway function in the control group (P < 0.01), while the small airway function was abnormal in 51 cases (56.7%). The difference between group A and group A was significant three months after administration (that is, group C and group A). There was a significant difference between group A and group A (group C and group A). There was a significant difference between group A and group B (group C and group D) after administration of medicine compared with group C and group A (group C and group A). There was a significant difference between group A and group B in the results of comparison between group A and group B (group C and group D) and control group (group C and group D) in comparison with those in group C and group A (group C and group D). There was a significant difference between group C and group D in comparison between group C and group D in group C and normal. There was no difference in contrast between group B and group B after three months of treatment (group D: group B: MMFF FEF75; group D: FEF75; group D: control group; Conclusion: some indexes of pulmonary function in patients with allergic rhinitis were decreased, mainly showed that small airway function was damaged. Nasal glucocorticoid was more effective than loratadine in improving pulmonary function of patients with allergic rhinitis.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R765.21
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本文编号：1962565