喉部良恶性病变患者外周血淋巴细胞与单核细胞比值及意义

发布时间：2018-06-04 08:58

  本文选题：喉肿瘤 + 喉癌前病变　； 参考：《临床耳鼻咽喉头颈外科杂志》2017年11期

【摘要】：目的:探讨术前外周血淋巴细胞单核细胞比值(LMR)在区分喉鳞状细胞癌(LSCC)、喉癌前病变(LPL)以及喉良性病变(LBL)中的作用。方法:收集405例经病理确诊的喉部病变患者(LSCC组154例,LPL组83例,LBL组168例),LSCC组按T分期进一步分为T1组、T2组和T3~4组,检测各组术前外周血中性粒细胞、淋巴细胞、单核细胞、血红蛋白和血小板等计数,并比较各组中LMR、中性粒细胞淋巴细胞比值(NLR)及其他指标。结果:LBL、LPL、LSCC各组中LMR和NLR值分别为4.88±1.65和4.61±1.59、3.92±1.77和2.11±0.79、2.08±0.77和2.63±1.69,LSCC组LMR较LBL组和LPL组小,且差异有统计学意义(P0.01),而NLR较LBL组和LPL组大(P0.05),LBL组和LPL组之间LMR和NLR差异均无统计学意义(P0.05)。LSCC组中局部晚期(T3~4期)患者较局部早、中期(T1、T2期)患者LMR小,而NLR值大且差别具有统计学意义(P0.05)。LBL、LPL、LSCC三组的血小板、白细胞、中性粒细胞数之间差异无统计学意义(P0.05)。结论:本研究首次比较不同喉部病变中的LMR,并发现LMR、NLR作为全身性的炎症指标对区分LSCC和LPL及LBL具有一定的参考价值。
[Abstract]:Objective: to investigate the role of LMRs in distinguishing LSCC, LPLs and LBLs in laryngeal squamous cell carcinoma (LSCC), precancerous laryngeal lesion (LPL) and benign laryngeal lesion (LBL) before operation. Methods: a total of 405 patients with laryngeal lesions diagnosed by pathology were collected. 154 patients in LPL group and 83 patients in LBL group were divided into T _ 1 group and T _ 2 group according to T staging. The peripheral blood neutrophils, lymphocytes and monocytes were detected in each group before operation. Hemoglobin and platelet count were compared and LMRs, neutrophil lymphocyte ratio (NLR) and other indexes were compared. Results the values of LMR and NLR were 4.88 卤1.65 and 4.61 卤1.59 卤3.92 卤1.77 and 2.11 卤0.79 卤2.08 卤0.77 and 2.63 卤1.69 in the LSCC group respectively, and the LMR values in the LSCC group were lower than those in the LBL group and LPL group. There was no significant difference in LMR and NLR between LBL group and LPL group. There was no significant difference in LMR and NLR between LBL group and LPL group. There was no significant difference in the number of platelets, leukocytes and neutrophils among the three groups. Conclusion: LMRs in different laryngeal lesions were compared for the first time in this study, and it was found that LMR-NLR was useful in differentiating LSCC from LPL and LBL.
【作者单位】： 复旦大学附属中山医院耳鼻咽喉头颈外科;
【基金】：上海市科委基金(No:14DZ1940703) 中山医院青年基金(No:2016ZSQN41)
【分类号】：R739.65
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本文编号：1976780