耳鼻喉术后并发感染患者的血清炎症因子、T淋巴细胞亚群表达及临床意义研究

发布时间：2018-06-10 21:05

  本文选题：耳鼻喉 + 感染　； 参考：《中华医院感染学杂志》2017年02期

【摘要】：目的研究耳鼻喉术后并发感染患者的血清炎症因子、T淋巴细胞亚群等临床指标的表达水平和临床意义,为耳鼻喉术后并发感染的临床诊治提供依据。方法选取2013年12月-2014年12月医院收治的耳鼻喉手术患者68例,根据患者术后是否并发感染分成了感染组和非感染组,各34例,对两组患者的C-反应蛋白(CRP)、白介素-8(IL-8)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和CD3+、CD4+、NK细胞百分比以及住院时间和抗菌药物使用时间进行观察和比较。结果感染组患者的CRP、IL-8、IL-6、TNF-α分别为(18.73±4.32)mg/L、(33.87±3.28)ng/ml、(30.28±4.32)ng/ml、(5.87±1.38)ng/ml,高于非感染组的(8.92±2.18)mg/L、(20.86±3.19)ng/ml、(15.97±2.39)ng/ml、(1.83±0.63)ng/ml;感染组患者的CD3+、CD4+、NK细胞百分比分别为(47.83±5.34)%、(39.28±5.43)%、(20.35±6.54)%,低于非感染组的(57.42±7.34)%、(48.34±7.53)%、(38.27±8.01)%;感染组患者的住院时间和抗菌药物使用时间分别为(10.83±1.81)d和(8.81±1.21)d,高于非感染组的(7.18±1.61)d和(5.19±1.02)d,差异均有统计学意义(P0.05)。结论术后并发感染可导致耳鼻喉手术患者血清炎症因子水平的升高和T淋巴细胞亚群相关指标的降低,不利于患者术后恢复,针对耳鼻喉术后感染实施有针对性的预防和干预具有重要的临床意义。
[Abstract]:Objective to study the expression level and clinical significance of serum inflammatory factor T lymphocyte subsets in patients complicated with infection after otolaryngectomy, so as to provide basis for clinical diagnosis and treatment of infection after otolaryngectomy. Methods Sixty-eight patients undergoing otolaryngectomy were selected from December 2013 to December 2014. According to whether the patients were complicated with infection after operation, they were divided into infection group and non-infection group, 34 cases each. The percentage of C- reactive protein (CRP), interleukin-8 (IL-8), interleukin-6 (IL-6), tumor necrosis factor- 伪 (TNF- 伪), CD3 + CD4 ~ + NK cells, and the duration of hospitalization and antibiotic use were observed and compared between the two groups. 缁撴灉鎰熸煋缁勬偅鑰呯殑CRP,IL-8,IL-6,TNF-伪鍒嗗埆涓，

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