同型半胱氨酸及血尿酸与感音神经性聋相关性的研究

发布时间：2018-06-12 10:00

本文选题：非遗传性获得性感音神经性聋 + 血清同型半胱氨酸　；参考：《辽宁中医药大学》2012年硕士论文

【摘要】：目的：观察无明显诱因及原发病的非遗传性获得性感音神经性耳聋（acquirednonhereditary sensorineural hearing loss以下简称神经性聋）患者血清同型半胱氨酸（hcy）和血尿酸水平，分析其与神经性聋的相关性。方法：收集神经性聋患者80例为实验组，选择性别、年龄等与实验组相匹配的正常听力人群80例作为对照组。采用以小分子捕获技术为基础的自动化速率法测定血清Hcy和TOOS的酶比色测定法测定血尿酸的含量。结果：实验组血清Hcy水平（18.54±4.34）μmol/L，显著高于对照组（8.02±3.54）μmol/L，实验组血尿酸水平（396.2±97.3）μmol/L，显著高于对照组（212.8±71.5）μmol/L，均有显著差异（P＜0.05）。结论：同型半胱氨酸、血尿酸与感音神经性聋有相关性，可能为感音神经性聋的危险因素之一。控制机体内同型半胱氨酸与血尿酸含量可以为耳聋的预防提出新的研究方向。
[Abstract]:Objective: to observe the serum homocysteine (Hcy) and serum uric acid (uric acid) levels in patients with non-hereditary acquired sensorineural hearing loss (sensorineural hearing loss) without obvious inducement. Methods: 80 cases of neurodeafness were collected as experimental group, and 80 cases of normal hearing group matched with experimental group were selected as control group. Serum Hcy and TOOS were determined by enzyme colorimetry based on small molecule capture technique. Results: the serum Hcy level of the experimental group was 18.54 卤4.34 渭 mol / L, significantly higher than that of the control group (8.02 卤3.54) 渭 mol / L, and that of the experimental group was 8.02 卤3.54 渭 mol 路L ~ (-1). Compared with the control group (212.8 卤71.5) 渭 mol / L, the difference was significant (P < 0.05). Conclusion: homocysteine, homocysteine, Serum uric acid is associated with sensorineural hearing loss and may be one of the risk factors for sensorineural hearing loss. Controlling the contents of homocysteine and uric acid in the body can provide a new research direction for the prevention of deafness.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R764

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