乙酰半胱氨酸药用联合双水平气道正压通气治疗重叠综合征的疗效

发布时间：2018-06-15 19:57

本文选题：重叠综合征 + 乙酰半胱氨酸　；参考：《临床肺科杂志》2016年10期

【摘要】：目的研究乙酰半胱氨酸药用联合双水平气道正压通气治疗重叠综合征的疗效。方法选取2013年7月至2015年3月期间本院收治的88例重叠综合征,按照随机数表法分为观察组和对照组,每组44例。对照组采取双水平气道正压通气,观察组在对照组基础上联合乙酰半胱氨酸药用。比较两组患者治疗后的临床疗效和治疗前后血清、肺功能及血气指标变化。结果治疗后,观察组患者总的有效率为93.18%(41/44)明显比对照组高77.27%(34/44),差异具有统计学意义(P0.05);观察组的SOD(51.21±3.01)u U/L、IL-6(5.03±1.11)ng/L指标要明显比对照组低(65.93±3.12)u U/L、(6.74±1.22)ng/L,观察组的IL-8(10.21±2.21)ng/L要高于对照组(7.32±1.54)ng/L,差异具有统计学意义(P0.05);观察组的FEV1、FEV1%、FEV1/FVC、FVC肺功能指标分别为(1.97±0.49)L、(54.33±12.46)%、(54.56±6.07)%、(54.21±10.31)%,高于对照组(P0.05);观察组的PaCO_2(32.14±5.01)mm Hg低于对照组(36.32±5.32)mm Hg,PaO_2(82.32±5.21)mm Hg高于对照组(73.21±4.76)mm Hg。结论重叠综合征患者采取乙酰半胱氨酸药用并联合双水平气道正压通气进行治疗,患者的血清指标、血气情况及肺功能均可得到明显的改善,临床疗效较好。
[Abstract]:Objective to study the therapeutic effect of acetylcysteine combined with double level positive airway pressure ventilation on overlap syndrome. Methods from July 2013 to March 2015 88 cases of overlap syndrome were divided into observation group and control group with 44 cases in each group. Two-level positive airway pressure ventilation was used in the control group and acetylcysteine was used in the observation group on the basis of the control group. The changes of serum, pulmonary function and blood gas were compared before and after treatment. Results after treatment, The total effective rate of the observation group was 93.18% 41 / 44) significantly higher than that of the control group (77.27% / 44), and the difference was statistically significant (P 0.05), and the SODV 51.21 卤3.01 U / L IL-6 / L index in the observation group was significantly lower than that in the control group (65.93 卤3.12 U / L = 6.74 卤1.22 ng / L), and the level of IL-810.21 卤2.21 ng / L in the observation group was significantly higher than that in the control group (7.32 卤1.54 ngL / L, P 0.05g / L). The pulmonary function indexes of FEV _ 1 / FEV _ 1 / FEV _ 1 / FV _ 1 / FV _ 1 / FVC in the observation group were 1.97 卤0.49, 54.33 卤12.46 and 54.56 卤6.07 respectively, which were higher than those in the control group (P 0.05), and the Paco _ 2o _ (22) 卤5.01)mm _ (2) Hg of the observation group was lower than that of the control group's (36.32 卤5.32)mm) HgPao _ 22.32 卤5.21)mm _ g _ (73.21 卤4.76)mm). Conclusion the patients with overlapping syndrome were treated with acetylcysteine combined with bilevel positive airway pressure ventilation. The serum indexes, blood gas and lung function of the patients were significantly improved, and the clinical effect was better.
【作者单位】：襄阳市中心医院呼吸二科;
【分类号】：R563.9;R766

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