阻塞性睡眠呼吸暂停低通气综合征与甲状腺转录因子-1、甲状腺激素的相关性分析

发布时间：2018-06-15 20:04

本文选题：阻塞性睡眠呼吸暂停低通气综合征 + 高血压　；参考：《新疆医科大学》2017年硕士论文

【摘要】：目的:探讨血清甲状腺激素、甲状腺转录因子-1(TTF-1)与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的相关性。方法:回顾性分析2015年1月-2015年12月在新疆维吾尔自治区人民医院高血压科就诊的338例可疑OSAHS患者,并行多导睡眠监测(PSG),根据呼吸暂停低通气指数(AHI)分为非OSAHS组及轻度、中度和重度OSAHS组。分别从非OSAHS组和重度OSAHS组各随机抽取40例患者,检测两组的血清TTF-1浓度,以及4组患者的甲状腺功能;并分析其与OSAHS的相关性。结果:根据呼吸暂停低通气指数(AHI)将入选的338例患者分为4分组:非OSAHS组134例、轻度OSAHS组69例、中度OSAHS组58例、重度OSAHS组77例。研究观察的40例非OSAHS患者和40例重度OSAHS患者的血清TTF-1水平,发现两组间的TTF-1水平未见明显差异(P0.05)。4组患者甲状腺激素的比较显示,游离甲状腺素(FT4)水平随OSAHS严重程度加重而增加(P0.05)。相关性分析显示FT4与性别、AHI和PRA存在明显的相关性。多元线性回归分析提示:AHI、体重指数(BMI)和肾素活性(PRA)可能是影响OSAHS患者FT4水平变化的危险因素(P0.05)结论:1.OSAHS患者TTF-1水平未见明显的改变,TTF-1可能不能作为筛查OSAHS的生物标志物。2.OSAHS可引起甲状腺激素水平的变化,AHI、BMI和PRA是影响OSAHS患者FT4水平的主要危险因素,提示OSAHS可能是甲状腺疾病发生的危险因素。
[Abstract]:Aim: to investigate the relationship between serum thyroid hormone, thyroid transcription factor -1 and OSAHS1 in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: a retrospective analysis of 338 suspected OSAHS patients from January 2015 to December 2015 in the Department of Hypertension, Xinjiang Uygur Autonomous region people's Hospital, was performed. The patients were divided into non-OSAHS group and mild OSAHS group according to apnea hypopnea index (AHII). Moderate and severe OSAHS groups. The serum TTF-1 concentration and thyroid function were measured in 40 patients from non-OSAHS group and 40 patients with severe OSAHS group, and the correlation between TTF-1 and OSAHS was analyzed. Results: according to apnea hypopnea index (AHI), 338 patients were divided into 4 groups: nonOSAHS group (n = 134), mild OSAHS group (n = 69), moderate OSAHS group (n = 58) and severe OSAHS group (n = 77). The serum TTF-1 levels of 40 non-OSAHS patients and 40 severe OSAHS patients were observed. There was no significant difference in TTF-1 levels between the two groups. The results showed that the level of free thyroxine FT4 increased with the severity of OSAHS. Correlation analysis showed that FT4 was significantly correlated with AHI and PRA. Multiple linear regression analysis suggested that the weight index (BMI) and renin activity (PRA) might be the risk factors influencing the change of FT4 level in OSAHS patients (P 0.05) conclusion: 1. TTF-1 level in OSAHS patients does not change significantly. TTF-1 may not be a biological marker for OSAHS screening. OSAHS may cause changes in thyroid hormone levels. AHI BMI and PRA are the main risk factors affecting FT4 levels in OSAHS patients. The results suggest that OSAHS may be a risk factor for thyroid disease.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R766

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