益生菌治疗变应性鼻炎临床疗效的Meta分析

发布时间：2018-06-16 15:14

本文选题：益生菌 + 鼻炎　；参考：《临床耳鼻咽喉头颈外科杂志》2017年06期

【摘要】：目的:系统性评价益生菌对变应性鼻炎的疗效。方法:系统检索PubMed、The Cochrane Library、Web of SCIence和万方、中国知网、中国生物医学、维普数据库,检索以益生菌为干预措施治疗变应性鼻炎的随机对照试验,检索时限均从建库截至2016年4月。由2名研究者按照纳入与排除标准独立筛选文献、提取资料并评价质量,采用RevMan 5.2软件进行Meta分析。结果:最终纳入17个随机对照实验,共1 374例患者,其中益生菌组809例,安慰剂组568例。Meta分析结果显示:益生菌组的总体、鼻部和眼部RQLQ评分、血清嗜酸粒细胞计数均较安慰剂组降低,差异有统计学意义(MD=-4.43,CI为-8.65~-0.20;MD=-1.08,CI为-1.89~0.27;MD=-0.95,CI为-1.46~-1.44;MD=-28.40,CI为-43.53~-13.26);益生菌组的血清IgE水平与安慰剂组差异无统计学意义;乳酸菌组与双歧杆菌组治疗后NTSS值差异无统计学意义(P0.05)。结论:与安慰剂组相比较,益生菌组对变应性鼻炎患者的症状改善明显,且不同菌属的益生菌治疗变应性鼻炎疗效差异无统计学意义。
[Abstract]:Objective: to systematically evaluate the effect of probiotics on allergic rhinitis. Methods: a systematic retrieval of PubMed, The Cochrane Library, Web of SCIence and Wanfang, Chinese knowledge network, Chinese biomedicine, VP database, and search for the treatment of allergic rhinitis with probiotics as intervention measures, the retrieval time from construction to April 2016. 2 researchers screened the literature independently, extracted the data and evaluated the quality according to the inclusion and exclusion criteria, and used the RevMan 5.2 software for Meta analysis. Results: the final inclusion of 17 randomized controlled trials in 1374 patients, 809 of the probiotics group and 568 in the placebo group, showed that the overall of the probiotics group, the nasal and eye RQLQ evaluation. The serum eosinophil counts were lower than those in the placebo group (MD=-4.43, CI -8.65~-0.20; MD=-1.08, CI -1.89~0.27; MD=-0.95, CI as -1.46~-1.44; MD=-28.40, CI was -43.53~-13.26); the serum levels of probiotics group were not statistically significant to placebo group; lactic acid bacteria group and Bifidobacterium group were treated after treatment. There was no significant difference in SS value (P0.05). Conclusion: compared with the placebo group, the probiotics group improved the symptoms of allergic rhinitis, and there was no significant difference in the therapeutic effect of the probiotics of different bacteria in the treatment of allergic rhinitis.
【作者单位】：吉林大学第二医院耳鼻咽喉头颈外科;
【基金】：吉林省教育厅“十二五”科学技术研究项目(No:2015514)
【分类号】：R765.21

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