喉癌中高危型HPV、ATM表达及临床意义

发布时间：2018-06-16 14:30

本文选题：喉癌 + ATM　；参考：《实用医学杂志》2016年18期

【摘要】：目的:通过检测喉癌患者肿瘤组织中ATM及HPV的表达,分析其与预后的关系。以探讨ATM,HPV在喉癌发生发展中的作用。方法:采用PCR法检测63例肿瘤组织和63例癌旁周围正常喉组织HPV16/18表达情况,免疫组化法检测63例肿瘤组织和30例癌旁周围正常喉组织的ATM蛋白的表达。Kaplan-Meier法行生存分析。结果 :63例喉鳞癌组织中,HPV16/18阳性率为39.7%,癌旁组织HPV16/18阳性率为9.5%,差异具有统计学意义(P0.05)。ATM蛋白在喉癌和癌旁组织中的阳性表达率分别为41.3%和83.3%,差异具有统计学意义(P0.05)。HPV16/18与ATM表达之间无相关性。喉癌HPV16/18阳性组5年生存率为56.0%,阴性组5年生存率为52.6%,差异无统计学意义(P0.05);63例喉癌ATM蛋白表达阳性组的5年生存率为65.4%,阴性组5年生存率为45.9%,差异无统计学意义(P0.05)。结论:喉癌中HPV16/18、ATM蛋白表达异常,HPV与ATM蛋白表达无相关性且两者表达与喉癌预后无关。
[Abstract]:Objective: to investigate the relationship between ATM and HPV expression and prognosis in laryngeal carcinoma. Objective to investigate the role of HPV in the development of laryngeal carcinoma. Methods: the expression of HPV16 / 18 in 63 cases of tumor tissues and 63 cases of adjacent normal laryngeal tissues were detected by PCR, and the expression of ATM protein in 63 cases of tumor tissues and 30 cases of adjacent normal larynx tissues were detected by immunohistochemical method. The survival analysis was performed by Kaplan-Meier method. Results the positive rate of HPV16 / 18 was 39.7in 63 cases of laryngeal squamous cell carcinoma and 9.5in adjacent tissues of laryngeal squamous cell carcinoma. The difference was statistically significant (41.3% and 83.3% in laryngeal carcinoma and paracancerous tissues, respectively). The difference was statistically significant (P0.05%. HPV1618 / 18). There was no correlation with ATM expression. The 5-year survival rate was 56.0 in HPV16 / 18 positive group and 52.6 in negative group. The 5-year survival rate of 63 cases of laryngeal carcinoma with positive expression of ATM protein was 65.4% and that of negative group was 45.9%. Conclusion: there is no correlation between HPV 16 / 18 ATM protein expression and ATM protein expression in laryngeal carcinoma, and there is no correlation between the expression of HPV and ATM protein expression and prognosis of laryngeal carcinoma.
【作者单位】：海南医学院附属医院耳鼻咽喉科;
【基金】：海南省卫生厅重点项目(编号:1441320.41A1004) 海南省科协青年科技英才学术创新计划项目(编号:HAST201634) 海南医学院附属医院科研培育基金资助
【分类号】：R739.65

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